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PI4KA and CD4
Number of citations of the paper that reports this interaction (PMID
8246987
)
26
Data Source:
HPRD
(in vitro)
PI4KA
CD4
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
CD4 molecule
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Golgi-associated Vesicle Membrane
Extracellular Vesicular Exosome
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
T Cell Receptor Complex
Membrane Raft
Molecular Function
1-phosphatidylinositol 4-kinase Activity
Protein Binding
ATP Binding
Glycoprotein Binding
Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Binding
Protein Homodimerization Activity
Biological Process
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Signal Transduction
Small Molecule Metabolic Process
Phosphatidylinositol Phosphorylation
Phosphatidylinositol-mediated Signaling
Cytokine Production
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Viral Process
T Cell Differentiation
Entry Into Host Cell
T Cell Costimulation
Maintenance Of Protein Location In Cell
T Cell Selection
Positive Regulation Of Interleukin-2 Biosynthetic Process
Innate Immune Response
Protein Palmitoleylation
Positive Regulation Of Protein Kinase Activity
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Pathways
Synthesis of PIPs at the Golgi membrane
Metabolism of lipids and lipoproteins
Synthesis of PIPs at the ER membrane
Phospholipid metabolism
PI Metabolism
Vpu mediated degradation of CD4
Downstream TCR signaling
Generation of second messenger molecules
Translocation of ZAP-70 to Immunological synapse
Costimulation by the CD28 family
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
HIV Infection
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
Early Phase of HIV Life Cycle
HIV Life Cycle
TCR signaling
Alpha-defensins
PD-1 signaling
Defensins
Phosphorylation of CD3 and TCR zeta chains
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Response to Vitamin E supplementation (
22437554
)
Protein-Protein Interactions
9 interactors:
C8orf33
CD4
CD7
LCK
MRPL44
MTNR1B
PITPNA
STRN4
TNNT1
38 interactors:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCH4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
Entrez ID
5297
920
HPRD ID
08972
01740
Ensembl ID
ENSG00000241973
ENSG00000010610
Uniprot IDs
B4DYG5
J3KN10
P42356
Q4LE69
B0AZV7
B4DT49
P01730
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4JM2
Enriched GO Terms of Interacting Partners
?
Regulation Of Defense Response To Virus By Virus
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Lymphocyte Activation
T Cell Costimulation
Regulation Of Defense Response To Virus
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Leukocyte Activation
Single Organismal Cell-cell Adhesion
T Cell Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Muscle Contraction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Differentiation
Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Homotypic Cell-cell Adhesion
Slow-twitch Skeletal Muscle Fiber Contraction
Enzyme Linked Receptor Protein Signaling Pathway
Lymphocyte Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Uterine Smooth Muscle Contraction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Gamma-delta T Cell Differentiation
Modulation By Virus Of Host Process
Cellular Zinc Ion Homeostasis
Positive Regulation Of Interleukin-2 Biosynthetic Process
Leukocyte Differentiation
Zinc Ion Homeostasis
Cell Adhesion
Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Positive Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Locomotion
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
Immune Response
Immune System Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Regulation Of T Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell Activation
Positive Regulation Of Cell-cell Adhesion
T Cell Costimulation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Response To Stimulus
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Immune Response
Signaling
Immune Response
Cell Communication
Signal Transduction
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Leukocyte Aggregation
Cellular Response To Stimulus
Apoptotic Process
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Programmed Cell Death
Response To Stress
Leukocyte Migration
Leukocyte Activation
Cell Death
Death
Cell Activation
Defense Response
Homeostatic Process
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Locomotion
Cell Migration
Cell Motility
Single Organismal Cell-cell Adhesion
Cellular Chemical Homeostasis
Tagcloud
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Difference)
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Intersection)
?