PI4KA and PITPNA

Number of citations of the paper that reports this interaction (PMID 7761838)
28

Data Source:
HPRD (in vivo)

		PI4KA	PITPNA
Gene Name		phosphatidylinositol 4-kinase, catalytic, alpha	phosphatidylinositol transfer protein, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Membrane Golgi-associated Vesicle Membrane Extracellular Vesicular Exosome	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding	Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transporter Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling	Lipid Metabolic Process Axon Guidance Visual Perception Phospholipid Transport
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Synthesis of PIPs at the ER membrane Phospholipid metabolism PI Metabolism	Axon guidance Role of second messengers in netrin-1 signaling Netrin-1 signaling
Drugs			1,2-Diacyl-Sn-Glycero-3-Phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS
Protein-Protein Interactions		9 interactors: C8orf33 CD4 CD7 LCK MRPL44 MTNR1B PITPNA STRN4 TNNT1	8 interactors: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2
Entrez ID		5297	5306
HPRD ID		08972	02548
Ensembl ID		ENSG00000241973	ENSG00000174238
Uniprot IDs		B4DYG5 J3KN10 P42356 Q4LE69	B4E1U1 Q00169
PDB IDs			1UW5
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Lymphocyte Activation T Cell Costimulation Regulation Of Defense Response To Virus Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Leukocyte Activation Single Organismal Cell-cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Muscle Contraction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Cell Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Slow-twitch Skeletal Muscle Fiber Contraction Enzyme Linked Receptor Protein Signaling Pathway Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Uterine Smooth Muscle Contraction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Gamma-delta T Cell Differentiation Modulation By Virus Of Host Process Cellular Zinc Ion Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Leukocyte Differentiation Zinc Ion Homeostasis Cell Adhesion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Immune Response	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Response To External Stimulus Neuron Development Cellular Lipid Metabolic Process Cell Morphogenesis Phosphatidylinositol-mediated Signaling Neuron Differentiation Cell Projection Organization Locomotion Lipid Metabolic Process Regulation Of Phosphorylation Anatomical Structure Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Lipid Modification Response To Organic Substance Response To Epidermal Growth Factor Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Generation Of Neurons Phosphate-containing Compound Metabolic Process Regulation Of Kinase Activity Neurogenesis Regulation Of Blood Vessel Endothelial Cell Migration Cell Development Inositol Phosphate Metabolic Process Activation Of Phospholipase C Activity Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Signal Transduction Activation Of MAPKK Activity Phospholipid Metabolic Process Organophosphate Metabolic Process Response To Stimulus Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Signaling
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