KITLG and CMA1

Number of citations of the paper that reports this interaction (PubMedID 10224464)
0

Data Source:
HPRD (in vitro)

		KITLG	CMA1
Description		KIT ligand	chymase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Filopodium Cell Projection	Extracellular Region Extracellular Space Cytosol Secretory Granule Extracellular Matrix Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process	Ovarian Follicle Development Neural Crest Cell Migration Hematopoietic Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Developmental Process Involved In Reproduction Apoptotic Process Cell Adhesion Ras Protein Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Melanocyte Migration Mast Cell Migration Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Angiotensin Maturation Proteolysis Peptide Metabolic Process Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Protein Maturation Cellular Response To Glucose Stimulus Cytokine Precursor Processing
Pathways			Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs			Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases		Familial progressive hyperpigmentation
GWAS		Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Facial skin colour (CIELAB index b* value) ( 34648798) Facial skin colour (CIELAB index L* value) ( 34648798) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240 23666239 19483681) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD S100A6 UBE2V1	10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		4254	1215
HPRD ID		01698	00346
Ensembl ID		ENSG00000049130	ENSG00000092009
Uniprot IDs		P21583	P23946 Q4FEB3
PDB IDs		1EXZ 1SCF 2E9W 8DFM 8DFP 8DFQ	1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP 7H60 7H61 7H62 7H63 7H64 7H65 7H66 7H67 7H68 7H69 7H6A 7H6B 7H6C 7H6D 7H6E 7H6F 7H6I 9GBH 9GC1 9GC9 9GCC 9GCD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mast Cell Migration Erythropoietin-mediated Signaling Pathway Mononuclear Cell Differentiation Leukocyte Differentiation B Cell Differentiation Regulation Of Cell Population Proliferation Myeloid Leukocyte Differentiation Embryonic Hemopoiesis Embryonic Organ Development Positive Regulation Of Leukocyte Proliferation Mast Cell Degranulation B Cell Activation Leukocyte Activation Dendritic Cell Differentiation Leukocyte Degranulation Extracellular Region Cell Activation Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Leukocyte Proliferation Developmental Process Extracellular Space Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Erythropoietin Receptor Activity Lysosome Localization Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Error-free Postreplication DNA Repair Basement Membrane Disassembly Signal Transduction Lymphocyte Activation Regulated Exocytosis Cytoplasmic Side Of Plasma Membrane Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Natural Killer Cell Chemotaxis UBC13-MMS2 Complex Positive Regulation Of Cytokine Production Secretion Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide	Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vein Smooth Muscle Contraction Leukocyte Migration Vasoconstriction Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Systemic Arterial Blood Pressure Regulation Of Locomotion Positive Regulation Of Prostaglandin Biosynthetic Process Artery Smooth Muscle Contraction Neutrophil Chemotaxis Tonic Smooth Muscle Contraction Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Regulation Of Vasoconstriction Neutrophil Migration Granulocyte Chemotaxis Vascular Associated Smooth Muscle Contraction Granulocyte Migration Positive Regulation Of Fatty Acid Biosynthetic Process Hormone Activity Positive Regulation Of Heart Rate Positive Regulation Of Cellular Component Organization Circulatory System Process Regulation Of Lipid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Lipid Metabolic Process Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Heart Contraction Positive Regulation Of Fatty Acid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Small Molecule Metabolic Process Extracellular Region Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Muscle Contraction System Process Extracellular Space Cell Migration
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