KITLG and FLT3LG

Number of citations of the paper that reports this interaction (PMID 9590652)
1

Data Source:
HPRD (in vivo)

		KITLG	FLT3LG
Gene Name		KIT ligand	fms-related tyrosine kinase 3 ligand
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane	Extracellular Space Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding Protein Homodimerization Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Melanocyte Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS		Blond vs. brown hair color ( 17952075) Hair color ( 23548203) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		8 interactors: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	3 interactors: FLT3 KITLG PFN2
Entrez ID		4254	2323
HPRD ID		01698	02477
Ensembl ID			ENSG00000090554
Uniprot IDs		P21583	B7ZLY4 M0QYM9 P49771 Q05C96
PDB IDs		1EXZ 1SCF 2E9W	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?		Erythropoietin-mediated Signaling Pathway Mast Cell Differentiation Cellular Response To Erythropoietin Mast Cell Chemotaxis Leukocyte Differentiation Myeloid Leukocyte Differentiation Cytokine Production Leukocyte Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemopoiesis Mast Cell Degranulation Cell Activation Mast Cell Mediated Immunity Fc-epsilon Receptor Signaling Pathway Immune System Development Embryonic Hemopoiesis Lysosome Localization Lymphocyte Differentiation Mast Cell Activation Myeloid Cell Differentiation Fc Receptor Signaling Pathway Leukocyte Degranulation Positive Regulation Of Cell Proliferation Organ Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulated Secretory Pathway Cellular Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Developmental Process Lymphocyte Activation Immune System Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Error-free Postreplication DNA Repair Mast Cell Proliferation Interleukin-1 Beta Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of JAK-STAT Cascade Embryonic Organ Development Reproductive Structure Development Reproductive System Development Immune Response Regulation Of Immune System Process Leukocyte Chemotaxis Response To Organic Substance T Cell Receptor Signaling Pathway System Development Kit Signaling Pathway	Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Pro-T Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mast Cell Apoptotic Process Pro-B Cell Differentiation Negative Regulation Of Ruffle Assembly Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Positive Regulation Of Melanocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Lymphoid Progenitor Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Hemopoiesis Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Ruffle Assembly Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Regulation Of Developmental Pigmentation
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?