KITLG and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 25241761)
0

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		KITLG	FLT3LG
Description		KIT ligand	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Filopodium Cell Projection	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Ovarian Follicle Development Neural Crest Cell Migration Hematopoietic Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Developmental Process Involved In Reproduction Apoptotic Process Cell Adhesion Ras Protein Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Melanocyte Migration Mast Cell Migration Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation
Pathways			PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs
Diseases		Familial progressive hyperpigmentation
GWAS		Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Facial skin colour (CIELAB index b* value) ( 34648798) Facial skin colour (CIELAB index L* value) ( 34648798) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240 23666239 19483681) Youthful appearance (self-reported) ( 32339537)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		9 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD S100A6 UBE2V1	5 interacting genes: FLT3 KITLG KRTAP5-9 PFN2 S100A6
Entrez ID		4254	2323
HPRD ID		01698	02477
Ensembl ID		ENSG00000049130	ENSG00000090554
Uniprot IDs		P21583	B7ZLY4 P49771
PDB IDs		1EXZ 1SCF 2E9W 8DFM 8DFP 8DFQ	1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mast Cell Migration Erythropoietin-mediated Signaling Pathway Mononuclear Cell Differentiation Leukocyte Differentiation B Cell Differentiation Regulation Of Cell Population Proliferation Myeloid Leukocyte Differentiation Embryonic Hemopoiesis Embryonic Organ Development Positive Regulation Of Leukocyte Proliferation Mast Cell Degranulation B Cell Activation Leukocyte Activation Dendritic Cell Differentiation Leukocyte Degranulation Extracellular Region Cell Activation Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Leukocyte Proliferation Developmental Process Extracellular Space Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Erythropoietin Receptor Activity Lysosome Localization Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Error-free Postreplication DNA Repair Basement Membrane Disassembly Signal Transduction Lymphocyte Activation Regulated Exocytosis Cytoplasmic Side Of Plasma Membrane Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Natural Killer Cell Chemotaxis UBC13-MMS2 Complex Positive Regulation Of Cytokine Production Secretion Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide	Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure
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