PIK3CB and RAB5B

Number of citations of the paper that reports this interaction (PubMedID 11432782)
0

Data Source:
BioGRID (pull down)

		PIK3CB	RAB5B
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	RAB5B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Midbody	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding
	Biological Process	Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Leukocyte Mediated Immunity Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Endocytosis Autophagy Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Embryonic Cleavage Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs		Caffeine XL765
Diseases
GWAS		Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		13 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ	19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		5291	5869
HPRD ID		04234	01544
Ensembl ID		ENSG00000051382	ENSG00000111540
Uniprot IDs		B4DER4 P42338	P61020
PDB IDs			2HEI
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Biological Quality Regulation Of Cytoskeleton Organization Exploration Behavior Regulation Of Actin Filament Polymerization Fc-gamma Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Import Into Nucleus Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Transport Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Kidney Size Cellular Response To Peptide Hormone Stimulus 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Organelle Organization Fc Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cellular Response To Oxygen-containing Compound Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Size Cellular Response To UV Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Insulin Receptor Substrate Binding Cellular Response To Insulin Stimulus Positive Regulation Of Protein Localization To Nucleus Locomotory Exploration Behavior Response To Peptide Hormone Cellular Response To Light Stimulus Protein Transport	Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport
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