PIK3CB and DVL3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PIK3CB	DVL3
Gene Name		phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Cytosol
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Regulation Of Cell-matrix Adhesion Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cellular Calcium Ion Homeostasis Autophagy Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cell Migration Platelet Activation Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Embryonic Cleavage Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Platelet Aggregation Regulation Of Clathrin-mediated Endocytosis	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by Interleukins Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Downstream TCR signaling IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade	disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		10 interactors: AGTR2 ALAS1 DVL3 HCK HPS6 MME PIK3R1 PRKCD PRKCE YWHAQ	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		5291	1857
HPRD ID		04234	03222
Ensembl ID			ENSG00000161202
Uniprot IDs		B4DER4 P42338	Q92997
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Receptor Activity Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Lipid Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Exploration Behavior Platelet Activation Response To Fibroblast Growth Factor Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Wound Healing Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Endocytosis Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Wounding Cellular Localization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Dephosphorylation Activation Of Phospholipase C Activity Response To Organic Substance Regulation Of Lipid Metabolic Process Regulation Of Protein Localization	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?