DNAJC7 and UBE4B

Number of citations of the paper that reports this interaction (PubMedID 15189447)
0

Data Source:
HPRD (two hybrid)

		DNAJC7	UBE4B
Description		DnaJ heat shock protein family (Hsp40) member C7	ubiquitination factor E4B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	ATPase Activator Activity Protein Binding Heat Shock Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Folding Regulation Of Cellular Response To Heat	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Major depressive disorder x sex interaction ( 34099189)	Atrial fibrillation ( 29892015) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)
Interacting Genes		17 interacting genes: BTG3 DISC1 HSP90AA1 HUS1 LCOR MKNK1 NF1 OGT PGR RAD1 RAD9A RSPH1 SMAD2 SMAD9 SMURF1 TP53 UBE4B	27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		7266	10277
HPRD ID		07046	11659
Ensembl ID		ENSG00000168259	ENSG00000130939
Uniprot IDs		Q99615	O95155
PDB IDs			2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Intracellular Signal Transduction I-SMAD Binding Cellular Response To Ionizing Radiation Disordered Domain Specific Binding Response To Radiation DNA Damage Checkpoint Signaling Nucleoplasm Histone Deacetylase Binding Signal Transduction Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Double-stranded DNA 3'-5' DNA Exonuclease Activity Negative Regulation Of Cell Cycle Nucleus Cellular Response To Radiation SMAD Protein Complex Protein Localization To Organelle Meiotic Cell Cycle Checkpoint Signaling Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Neuroblast Proliferation Cytoplasm Striated Muscle Cell Apoptotic Process Transforming Growth Factor Beta Receptor Binding Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Salt Stress Muscle Cell Apoptotic Process DNA Replication Checkpoint Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Light Stimulus Apoptotic Signaling Pathway SMAD Protein Signal Transduction Establishment Of Protein Localization To Organelle Regulation Of Cellular Response To Growth Factor Stimulus R-SMAD Binding	Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process
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