DNAJC7 and HUS1

Number of citations of the paper that reports this interaction (PubMedID 11573955)
0

Data Source:
HPRD (in vitro, in vivo)

		DNAJC7	HUS1
Description		DnaJ heat shock protein family (Hsp40) member C7	HUS1 checkpoint clamp component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	ATPase Activator Activity Protein Binding Heat Shock Protein Binding	Protein Binding
	Biological Process	Protein Folding Regulation Of Cellular Response To Heat	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Regulation of HSF1-mediated heat shock response	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Major depressive disorder x sex interaction ( 34099189)	Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		17 interacting genes: BTG3 DISC1 HSP90AA1 HUS1 LCOR MKNK1 NF1 OGT PGR RAD1 RAD9A RSPH1 SMAD2 SMAD9 SMURF1 TP53 UBE4B	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		7266	3364
HPRD ID		07046	04787
Ensembl ID		ENSG00000168259	ENSG00000136273
Uniprot IDs		Q99615	A4D2F2 O60921
PDB IDs			3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Intracellular Signal Transduction I-SMAD Binding Cellular Response To Ionizing Radiation Disordered Domain Specific Binding Response To Radiation DNA Damage Checkpoint Signaling Nucleoplasm Histone Deacetylase Binding Signal Transduction Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Double-stranded DNA 3'-5' DNA Exonuclease Activity Negative Regulation Of Cell Cycle Nucleus Cellular Response To Radiation SMAD Protein Complex Protein Localization To Organelle Meiotic Cell Cycle Checkpoint Signaling Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Neuroblast Proliferation Cytoplasm Striated Muscle Cell Apoptotic Process Transforming Growth Factor Beta Receptor Binding Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Salt Stress Muscle Cell Apoptotic Process DNA Replication Checkpoint Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Light Stimulus Apoptotic Signaling Pathway SMAD Protein Signal Transduction Establishment Of Protein Localization To Organelle Regulation Of Cellular Response To Growth Factor Stimulus R-SMAD Binding	DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination
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