FLT3LG and PFN2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FLT3LG	PFN2
Gene Name		fms-related tyrosine kinase 3 ligand	profilin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding Protein Homodimerization Activity	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways			Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FLT3 KITLG PFN2	31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		2323	5217
HPRD ID		02477	01451
Ensembl ID		ENSG00000090554	ENSG00000070087
Uniprot IDs		B7ZLY4 M0QYM9 P49771 Q05C96	G5E9Q6 P35080
PDB IDs		1ETE 3QS7 3QS9	1D1J
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Pro-T Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mast Cell Apoptotic Process Pro-B Cell Differentiation Negative Regulation Of Ruffle Assembly Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Positive Regulation Of Melanocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Lymphoid Progenitor Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Hemopoiesis Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Ruffle Assembly Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Regulation Of Developmental Pigmentation	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly
Tagcloud ?			actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?			actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?