PHAX and ZWINT

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PHAX	ZWINT
Description		phosphorylated adaptor for RNA export	ZW10 interacting kinetochore protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Neuronal Cell Body Ribonucleoprotein Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Dendrite Knl1/Spc105 Complex
	Molecular Function	RNA Binding Protein Binding Toxic Substance Binding MRNA Cap Binding Complex Binding	Protein Binding
	Biological Process	SnRNA Export From Nucleus Protein Transport RNA Stabilization	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Homologous Chromosome Orientation In Meiotic Metaphase I Cell Division Establishment Of Localization In Cell Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		snRNP Assembly RNA polymerase II transcribes snRNA genes	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Colorectal cancer ( 30529582)	Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)
Interacting Genes		16 interacting genes: ASPSCR1 CDC42 GADD45G GRB7 MKNK1 NSFL1C OGT PDPK1 RAD23A RPS6KA1 TNFSF11 TULP3 UBXN2A VAV1 XPO1 ZWINT	17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10
Entrez ID		51808	11130
HPRD ID		15122	18366
Ensembl ID		ENSG00000164902	ENSG00000122952
Uniprot IDs		Q9H814	O95229
PDB IDs		2XC7 8PNT	8PPR
Enriched GO Terms of Interacting Partners?		Cytoplasm Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Organization Intracellular Signal Transduction Regulation Of Signal Transduction Nuclear Membrane Reassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Activation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling 3-phosphoinositide-dependent Protein Kinase Activity T Cell Costimulation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Organelle Localization Nuclear Membrane Organization Cell Projection Positive Regulation Of Cell Adhesion Leukocyte Migration GBD Domain Binding Storage Vacuole Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Bronchus Morphogenesis Cellular Response To Triglyceride Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I VCP-NSFL1C Complex Membrane Assembly Negative Regulation Of Protein Localization To Centrosome	Outer Kinetochore Positive Regulation Of Amyloid Fibril Formation Cell Division Mitotic Sister Chromatid Segregation Chromosome Segregation Sister Chromatid Segregation Skeletal Muscle Satellite Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore MIS12/MIND Type Complex Chromosome, Centromeric Region Nuclear Chromosome Segregation Kinetochore Organelle Organization Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell Intracellular Transport Segment Specification Kinetochore Organization Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Chromosome Organization Cellular Localization Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Protein Transport Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Spindle Pole Mitotic Cell Cycle Positive Regulation Of Endocytosis Establishment Of Mitotic Spindle Orientation Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Developmental Process Positive Regulation Of Nitric Oxide Metabolic Process Establishment Of Mitotic Spindle Localization Negative Regulation Of Mitotic Nuclear Division Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Establishment Of Integrated Proviral Latency T Cell Differentiation In Thymus Establishment Of Spindle Orientation
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