PHAX and GRB7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PHAX	GRB7
Description		phosphorylated adaptor for RNA export	growth factor receptor bound protein 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Neuronal Cell Body Ribonucleoprotein Complex	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Anchoring Junction
	Molecular Function	RNA Binding Protein Binding Toxic Substance Binding MRNA Cap Binding Complex Binding	RNA Binding Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	SnRNA Export From Nucleus Protein Transport RNA Stabilization	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		snRNP Assembly RNA polymerase II transcribes snRNA genes	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Colorectal cancer ( 30529582)	Asthma ( 28461288 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		16 interacting genes: ASPSCR1 CDC42 GADD45G GRB7 MKNK1 NSFL1C OGT PDPK1 RAD23A RPS6KA1 TNFSF11 TULP3 UBXN2A VAV1 XPO1 ZWINT	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		51808	2886
HPRD ID		15122	03311
Ensembl ID		ENSG00000164902	ENSG00000141738
Uniprot IDs		Q9H814	A0A0S2Z4F6 Q14451
PDB IDs		2XC7 8PNT	1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q 7MP3
Enriched GO Terms of Interacting Partners?		Cytoplasm Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Organization Intracellular Signal Transduction Regulation Of Signal Transduction Nuclear Membrane Reassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Activation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling 3-phosphoinositide-dependent Protein Kinase Activity T Cell Costimulation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Organelle Localization Nuclear Membrane Organization Cell Projection Positive Regulation Of Cell Adhesion Leukocyte Migration GBD Domain Binding Storage Vacuole Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Bronchus Morphogenesis Cellular Response To Triglyceride Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I VCP-NSFL1C Complex Membrane Assembly Negative Regulation Of Protein Localization To Centrosome	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Receptor Complex Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase Activity Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Adhesion Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process ERBB2 Signaling Pathway Transferase Activity Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Positive Regulation Of Protein Modification Process Cellular Developmental Process Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding ATP Binding Regulation Of Locomotion Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Regulation Of Developmental Process
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