PHAX and MKNK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PHAX	MKNK1
Description		phosphorylated adaptor for RNA export	MAPK interacting serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Neuronal Cell Body Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Toxic Substance Binding MRNA Cap Binding Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	SnRNA Export From Nucleus Protein Transport RNA Stabilization	Regulation Of Translation Protein Phosphorylation Intracellular Signal Transduction
Pathways		snRNP Assembly RNA polymerase II transcribes snRNA genes	Spry regulation of FGF signaling
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 34099189) Colorectal cancer ( 30529582)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		16 interacting genes: ASPSCR1 CDC42 GADD45G GRB7 MKNK1 NSFL1C OGT PDPK1 RAD23A RPS6KA1 TNFSF11 TULP3 UBXN2A VAV1 XPO1 ZWINT	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		51808	8569
HPRD ID		15122	09468
Ensembl ID		ENSG00000164902	ENSG00000079277
Uniprot IDs		Q9H814	A0A499FJN1 A0A499FJS1 A8K341 Q9BUB5
PDB IDs		2XC7 8PNT	2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?		Cytoplasm Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Golgi Organization Intracellular Signal Transduction Regulation Of Signal Transduction Nuclear Membrane Reassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Activation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling 3-phosphoinositide-dependent Protein Kinase Activity T Cell Costimulation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Organelle Localization Nuclear Membrane Organization Cell Projection Positive Regulation Of Cell Adhesion Leukocyte Migration GBD Domain Binding Storage Vacuole Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Bronchus Morphogenesis Cellular Response To Triglyceride Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I VCP-NSFL1C Complex Membrane Assembly Negative Regulation Of Protein Localization To Centrosome	Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Lung Morphogenesis Intracellular Signal Transduction Cellular Response To Nutrient Levels Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Gene Expression Negative Regulation Of Autophagy Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Translation Initiation Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling MAP Kinase Activity Regulation Of Translation Cytoplasm Regulation Of Defense Response Nucleus Intracellular Signaling Cassette Translation Factor Activity, RNA Binding Positive Regulation Of Defense Response Stress-activated MAPK Cascade Interleukin-34-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Translational Initiation Cell Death Stress-activated Protein Kinase Signaling Cascade Response To Growth Factor Regulation Of Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Developmental Process Cytoplasmic Stress Granule Thyroid Gland Development
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