TUBA8 and PXN

Number of citations of the paper that reports this interaction (PMID 10840040)
18

Data Source:
HPRD (in vivo, two hybrid)

		TUBA8	PXN
Gene Name		tubulin, alpha 8	paxillin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding
	Biological Process	Microtubule-based Process Protein Polymerization	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway
Pathways			Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs		Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GRM7 MYC PXN SIAH1 TCP1	73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1
Entrez ID		51807	5829
HPRD ID		05763	03937
Ensembl ID		ENSG00000183785	ENSG00000089159
Uniprot IDs		Q9NY65	E7EMK8 F5GZ78 P49023
PDB IDs			1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Morphogenesis Of A Branching Structure Conditioned Taste Aversion Regulation Of Signaling Negative Regulation Of Monocyte Differentiation Negative Regulation Of Glutamate Secretion Positive Regulation Of Cell Proliferation Involved In Kidney Development Cellular Protein Complex Assembly Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Macrophage Apoptotic Process Epithelial Tube Morphogenesis Regulation Of Cell Death Regulation Of Glutamate Secretion Tubulin Complex Assembly Regulation Of Monocyte Differentiation Signal Complex Assembly Short-term Memory Tube Morphogenesis Regulation Of Intracellular Signal Transduction G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Morphogenesis Of An Epithelium Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Protein Destabilization Growth Hormone Receptor Signaling Pathway Oxygen Transport Cellular Response To Growth Hormone Stimulus Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Focal Adhesion Assembly Regulation Of MAPK Cascade Positive Regulation Of Cell Death Negative Regulation Of CAMP Metabolic Process Cellular Macromolecular Complex Assembly Tissue Morphogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion
Tagcloud ?		abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Difference) ?		abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored	acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1
Tagcloud (Intersection) ?