NCOR2 and JUN

Number of citations of the paper that reports this interaction (PubMedID 10777532)
0

Data Source:
BioGRID (pull down)

		NCOR2	JUN
Description		nuclear receptor corepressor 2	Jun proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex Protein-containing Complex	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Enzyme Activator Activity Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lactation Regulation Of Ketone Metabolic Process Cerebellum Development Response To Estradiol Estrous Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Microglial Cell Activation Liver Development Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway JNK Cascade Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Epithelial Cell Migration Release From Viral Latency Monocyte Differentiation Axon Regeneration Response To Endoplasmic Reticulum Stress Leading Edge Cell Differentiation Response To Muscle Stretch Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Response To Steroid Hormone Regulation Of Cell Cycle SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Anisomycin Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants Regulation of PD-L1(CD274) transcription
Drugs			Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)
Interacting Genes		92 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CAMK2B CBFA2T2 CDK2 CEBPB CEP63 CHUK CIRSR CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 KPNA4 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBC UBE2I VDR YWHAE ZBTB16 ZBTB5 ZBTB7A	181 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GGA1 GGA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MECOM MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C
Entrez ID		9612	3725
HPRD ID		02910	01302
Ensembl ID		ENSG00000196498	ENSG00000177606
Uniprot IDs		C9J0Q5 C9JE98 Q9Y618	P05412
PDB IDs		1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ 7SQA 8AQM 8AQN 8B8W 8B8X 8B8Y 8B8Z 8B90 8B91 8B92 8B93 8B94 8B95 8X7E	1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V 8SOS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Binding Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex DNA-templated Transcription Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Cell Differentiation Transcription Cis-regulatory Region Binding Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription By RNA Polymerase II	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Regulation Of Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription By RNA Polymerase II Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Developmental Process Intracellular Signaling Cassette DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process
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