UIMC1 and FANCG

Number of citations of the paper that reports this interaction (PubMedID 25132264)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		UIMC1	FANCG
Description		ubiquitin interaction motif containing 1	FA complementation group G
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of Double-strand Break BRCA1-A Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Fanconi Anaemia Nuclear Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Damaged DNA Binding Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription DNA Repair-dependent Chromatin Remodeling	Ovarian Follicle Development DNA Repair DNA Damage Response Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases			Fanconi anemia
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 TRAIP UBB UBC USP13 WBP2 ZMYM3	44 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TCEANC TFIP11 TLE5 TPRX1 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1
Entrez ID		51720	2189
HPRD ID		11482	04262
Ensembl ID		ENSG00000087206	ENSG00000221829
Uniprot IDs		Q96RL1	O15287 Q53XM5
PDB IDs		2MKF 2MKG 2N9E 2RR9	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair DNA Damage Response Protein Tag Activity Proteasome Binding DNA Metabolic Process Regulation Of Cellular Response To Stress Nuclear Body Chromatin Organization Transcription Regulator Complex Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Post-translational Protein Modification Damaged DNA Binding Estrogen Response Element Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Mitotic DNA Integrity Checkpoint Signaling Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of DNA Repair Cellular Response To Estrogen Stimulus Response To Radiation Intracellular Signal Transduction DNA Damage Checkpoint Signaling Regulation Of Cell Cycle PML Body Regulation Of DNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Ubiquitin-like Protein Ligase Binding Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction By P53 Class Mediator Determination Of Adult Lifespan Positive Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription	DNA Metabolic Process DNA Damage Response DNA Repair Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Mitotic G2 DNA Damage Checkpoint Signaling Telomere Maintenance Via Recombination Mitotic G2/M Transition Checkpoint Mitotic Recombination Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Female Gonad Development Signal Transduction In Response To DNA Damage Nucleoplasm Nuclear Ubiquitin Ligase Complex Chromosome, Telomeric Region Golgi Disassembly Cellular Response To Stress Telomere Maintenance DNA Damage Checkpoint Signaling Regulation Of Glycoprotein Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle BRCA1-A Complex Chromosome Organization Centrosome Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of Cell Cycle Positive Regulation Of Glutamate Receptor Signaling Pathway Telomere Organization Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Gonad Development Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Primary Metabolic Process Meiosis I Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nucleus Cellular Response To Radiation Organelle Organization Regulation Of Embryonic Development Microtubule Organizing Center Organization Chromatin Reproductive Structure Development
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