UIMC1 and ABRAXAS1

Number of citations of the paper that reports this interaction (PubMedID 17525340)
27

Data Source:
HPRD (in vitro, in vivo)

		UIMC1	ABRAXAS1
Description		ubiquitin interaction motif containing 1	abraxas 1, BRCA1 A complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of Double-strand Break BRCA1-A Complex	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription DNA Repair-dependent Chromatin Remodeling	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Mitotic Spindle Assembly
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 TRAIP UBB UBC USP13 WBP2 ZMYM3	9 interacting genes: AKT1 BABAM1 BRCA1 CFTR OGT SUMO2 UBC UIMC1 ZMYM3
Entrez ID		51720	84142
HPRD ID		11482	08584
Ensembl ID		ENSG00000087206	ENSG00000163322
Uniprot IDs		Q96RL1	Q6UWZ7
PDB IDs		2MKF 2MKG 2N9E 2RR9	4JLU 4U4A 4Y18 4Y2G
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair DNA Damage Response Protein Tag Activity Proteasome Binding DNA Metabolic Process Regulation Of Cellular Response To Stress Nuclear Body Chromatin Organization Transcription Regulator Complex Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Post-translational Protein Modification Damaged DNA Binding Estrogen Response Element Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Mitotic DNA Integrity Checkpoint Signaling Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of DNA Repair Cellular Response To Estrogen Stimulus Response To Radiation Intracellular Signal Transduction DNA Damage Checkpoint Signaling Regulation Of Cell Cycle PML Body Regulation Of DNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Ubiquitin-like Protein Ligase Binding Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction By P53 Class Mediator Determination Of Adult Lifespan Positive Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription	BRCA1-A Complex Mitotic G2 DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Ubiquitin-modified Histone Reader Activity Positive Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Protein Tag Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Response To Radiation Positive Regulation Of DNA Repair Response To Ionizing Radiation Nucleoplasm Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Repair-dependent Chromatin Remodeling Protein K6-linked Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Regulation Of Lipid Biosynthetic Process 14-3-3 Protein Binding Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nucleus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Negative Regulation Of Fatty Acid Metabolic Process Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Protein Modification By Small Protein Conjugation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Response To Alcohol Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Protein-containing Complex Ubiquitin Protein Ligase Binding Regulation Of Lipid Metabolic Process Positive Regulation Of TORC1 Signaling
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