UIMC1 and ECPAS

Number of citations of the paper that reports this interaction (PubMedID 20682791)
103

Data Source:
BioGRID (two hybrid)

		UIMC1	ECPAS
Description		ubiquitin interaction motif containing 1	Ecm29 proteasome adaptor and scaffold
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of Double-strand Break BRCA1-A Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Trans-Golgi Network Centrosome Cytoskeleton Membrane COPII-coated ER To Golgi Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription DNA Repair-dependent Chromatin Remodeling	ERAD Pathway Proteasome Assembly
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 TRAIP UBB UBC USP13 WBP2 ZMYM3	36 interacting genes: AGTRAP ANK2 ANKRD17 BSND CCDC57 CEBPA CEP170B CKS1B CMTM5 CMTM6 CPD DGAT2L6 DNAJB9 DST FBXO2 GAREM2 GOLGB1 HNRNPM HSD17B13 HSPB1 MAL2 MKI67 MYH10 PCM1 PCYT1B RAB11FIP4 RNF168 SF3B2 SPECC1L SYNE1 TNFRSF10D UBE2G2 UBE2Q1 UIMC1 VPS11 ZNF483
Entrez ID		51720	23392
HPRD ID		11482	11078
Ensembl ID		ENSG00000087206	ENSG00000136813
Uniprot IDs		Q96RL1	A0AAA9X0G7 Q5VYK3
PDB IDs		2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair DNA Damage Response Protein Tag Activity Proteasome Binding DNA Metabolic Process Regulation Of Cellular Response To Stress Nuclear Body Chromatin Organization Transcription Regulator Complex Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Post-translational Protein Modification Damaged DNA Binding Estrogen Response Element Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Mitotic DNA Integrity Checkpoint Signaling Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of DNA Repair Cellular Response To Estrogen Stimulus Response To Radiation Intracellular Signal Transduction DNA Damage Checkpoint Signaling Regulation Of Cell Cycle PML Body Regulation Of DNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Ubiquitin-like Protein Ligase Binding Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction By P53 Class Mediator Determination Of Adult Lifespan Positive Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription
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