UIMC1 and ATP8A2

Number of citations of the paper that reports this interaction (PMID 17621610)
46

Data Source:
BioGRID (enzymatic study)

		UIMC1	ATP8A2
Gene Name		ubiquitin interaction motif containing 1	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus BRCA1-A Complex	Photoreceptor Outer Segment Endosome Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Histone Binding Retinoid X Receptor Binding K63-linked Polyubiquitin Binding	Magnesium Ion Binding Phospholipid-translocating ATPase Activity ATP Binding
	Biological Process	Double-strand Break Repair Transcription, DNA-templated Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination	Involuntary Skeletal Muscle Contraction Axonogenesis Aging Metabolic Process Negative Regulation Of Cell Proliferation Retina Layer Formation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Positive Regulation Of Multicellular Organism Growth Inner Ear Morphogenesis Eating Behavior Skin Development Phospholipid Translocation Neuron Development Neuromuscular Process Controlling Posture Detection Of Light Stimulus Involved In Visual Perception Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Translocation
Pathways			Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201)	Eating disorders ( 23568457)
Protein-Protein Interactions		14 interactors: ATP8A2 BABAM1 BRCC3 CEP57 ESR1 FAM175A FANCG HIST2H2AC INO80B KIAA0368 MDC1 NR6A1 SKIL TP53	1 interactors: UIMC1
Entrez ID		51720	51761
HPRD ID		11482	05795
Ensembl ID		ENSG00000087206	ENSG00000132932
Uniprot IDs		Q96RL1	B7Z880 Q6ZSP3 Q6ZU25 Q9NTI2
PDB IDs		2RR9
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Double-strand Break Repair DNA Repair DNA Damage Checkpoint Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Response To Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus DNA Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Chromatin Organization Regulation Of DNA Repair Cellular Response To Stress Organelle Organization Chromosome Organization Chromatin Modification Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Protein K63-linked Deubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Multicellular Organismal Reproductive Process Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organism Reproduction Protein Import Into Nucleus, Translocation Cellular Response To Stimulus Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Response To X-ray Spermatogenesis Male Gamete Generation Nitrogen Compound Metabolic Process Reproduction DNA-templated Transcription, Initiation Single Organism Reproductive Process Gamete Generation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Reproductive Process Rhythmic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovarian Follicle Development Sexual Reproduction Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process	Histone H2A K63-linked Deubiquitination Protein K63-linked Deubiquitination Histone Deubiquitination G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Protein Deubiquitination Protein Modification By Small Protein Removal Regulation Of Response To DNA Damage Stimulus Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair DNA Damage Checkpoint
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