UIMC1 and ATP8A2

Number of citations of the paper that reports this interaction (PubMedID 17621610)
44

Data Source:
BioGRID (enzymatic study)

		UIMC1	ATP8A2
Description		ubiquitin interaction motif containing 1	ATPase phospholipid transporting 8A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of Double-strand Break BRCA1-A Complex	Golgi Membrane Nucleoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endosome Membrane Endomembrane System Membrane Cell Projection Phospholipid-translocating ATPase Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Aminophospholipid Flippase Activity ATP Hydrolysis Activity Metal Ion Binding Phosphatidylethanolamine Flippase Activity Phosphatidylserine Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylserine Flippase Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription DNA Repair-dependent Chromatin Remodeling	Involuntary Skeletal Muscle Contraction Lipid Transport Axonogenesis Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Retina Layer Formation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Phospholipid Transport Positive Regulation Of Multicellular Organism Growth Inner Ear Morphogenesis Eating Behavior Skin Development Phospholipid Translocation Neuron Development Neuromuscular Process Controlling Posture Detection Of Light Stimulus Involved In Visual Perception Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Translocation Aminophospholipid Translocation
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Common carotid intima-media thickness ( 29206233) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Eating disorders ( 23568457) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 TRAIP UBB UBC USP13 WBP2 ZMYM3	1 interacting genes: UIMC1
Entrez ID		51720	51761
HPRD ID		11482	05795
Ensembl ID		ENSG00000087206	ENSG00000132932
Uniprot IDs		Q96RL1	A0A804HI09 A0A804HKW9 B7Z880 Q6ZU25 Q9NTI2
PDB IDs		2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair DNA Damage Response Protein Tag Activity Proteasome Binding DNA Metabolic Process Regulation Of Cellular Response To Stress Nuclear Body Chromatin Organization Transcription Regulator Complex Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Post-translational Protein Modification Damaged DNA Binding Estrogen Response Element Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Mitotic DNA Integrity Checkpoint Signaling Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of DNA Repair Cellular Response To Estrogen Stimulus Response To Radiation Intracellular Signal Transduction DNA Damage Checkpoint Signaling Regulation Of Cell Cycle PML Body Regulation Of DNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Ubiquitin-like Protein Ligase Binding Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction By P53 Class Mediator Determination Of Adult Lifespan Positive Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription	BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DNA Repair-dependent Chromatin Remodeling K63-linked Polyubiquitin Modification-dependent Protein Binding Mitotic G2 DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Positive Regulation Of DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Histone Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition
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