C14orf166 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		C14orf166	DISC1
Gene Name		chromosome 14 open reading frame 166	disrupted in schizophrenia 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm TRNA-splicing Ligase Complex	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Core Binding RNA Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Transport	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		4 interactors: DISC1 FAM98A GLP1R NIN	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		51637	27185
HPRD ID		16615	05553
Ensembl ID		ENSG00000087302	ENSG00000162946
Uniprot IDs		Q549M8 Q9Y224	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Centrosome-templated Microtubule Nucleation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Cellular Metal Ion Homeostasis Microtubule Cytoskeleton Organization Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Mitochondrial Calcium Ion Homeostasis Regulation Of Synapse Maturation Microtubule Nucleation Cellular Homeostasis TOR Signaling CAMP-mediated Signaling Microtubule-based Process Microtubule Polymerization Positive Regulation Of Neuroblast Proliferation Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Chemical Homeostasis Centrosome Localization Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Microtubule Polymerization Or Depolymerization Positive Regulation Of Lyase Activity Cell Proliferation In Forebrain Microtubule Anchoring Cytoskeleton Organization Response To Glucagon Regulation Of Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Stem Cell Proliferation Cellular Protein Localization Homeostatic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of Synapse Organization Cerebral Cortex Cell Migration Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		arch archaea archease asw c22orf28 c2orf49 cgi cooperation d10wsu52e ddx1 dead eukaryotes faap fam98b guanylate helicase hspc117 implies interplay ligase ligases ligation multimeric orthologous rtcb splicing trna trnas zbtb8os	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		arch archaea archease asw c22orf28 c2orf49 cgi cooperation d10wsu52e ddx1 dead eukaryotes faap fam98b guanylate helicase hspc117 implies interplay ligase ligases ligation multimeric orthologous rtcb splicing trna trnas zbtb8os	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?