TRIM43 and GRB7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM43	GRB7
Description		tripartite motif containing 43	growth factor receptor bound protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Regulation Of Gene Expression Innate Immune Response	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways			GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle
Drugs
Diseases
GWAS			Asthma ( 28461288 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		11 interacting genes: ENOX1 GRB7 MYOG TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G2 UBE2K	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		129868	2886
HPRD ID		15560	03311
Ensembl ID		ENSG00000144015	ENSG00000141738
Uniprot IDs		Q96BQ3	A0A0S2Z4F6 Q14451
PDB IDs			1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q 7MP3
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Protein Metabolic Process Regulation Of Viral Transcription ATP Binding Cellular Response To Interferon-beta Protein K6-linked Ubiquitination Response To Interferon-beta Protein K11-linked Ubiquitination Nucleotide Binding Catabolic Process Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Negative Regulation Of Viral Process Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Ultradian Rhythm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Cytokine Stimulus PML Body Regulation Of BMP Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Proteasomal Protein Catabolic Process Regulation Of Viral Process Response To Cytokine Free Ubiquitin Chain Polymerization Response To Denervation Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Phosphatidylinositol 3-kinase Inhibitor Activity Response To Peptide Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Receptor Complex Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase Activity Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Adhesion Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process ERBB2 Signaling Pathway Transferase Activity Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Positive Regulation Of Protein Modification Process Cellular Developmental Process Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding ATP Binding Regulation Of Locomotion Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Regulation Of Developmental Process
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