SNX4 and BIN1

Number of citations of the paper that reports this interaction (PMID 12668730)
13

Data Source:
HPRD (two hybrid, in vivo)

		SNX4	BIN1
Gene Name		sorting nexin 4	bridging integrator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane Extrinsic Component Of Membrane SNARE Complex Early Endosome Membrane Protein Complex	Nucleus Cytoplasm Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon I Band Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Protein Complex Binding Identical Protein Binding Protein Heterodimerization Activity Tau Protein Binding GTPase Binding RNA Polymerase Binding
	Biological Process	Protein Transport Vesicle Organization Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell	Endocytosis Cell Proliferation Viral Process Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Astrocyte Differentiation Lipid Tube Assembly Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 22832961 21460840 21627779 22005930) Alzheimer's disease (late onset) ( 21460841 21390209)
Protein-Protein Interactions		15 interactors: AGK ARL6IP1 ATP6V0A1 BIN1 EGFR HIVEP1 INSR LEPR MAGEA6 PDGFRA PDGFRB PTPN5 SNX2 SNX6 SUPT5H	36 interactors: ABL1 AMPH AP2A1 AP2A2 APP ASAP2 ATXN2 CUX1 DLGAP4 DNM1 DNM2 FBP1 ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC XRCC4 ZBTB3
Entrez ID		8723	274
HPRD ID		09334	03150
Ensembl ID		ENSG00000114520	ENSG00000136717
Uniprot IDs		O95219	B7Z6Y2 O00499 Q9BTH3
PDB IDs			1MUZ 1MV0 1MV3 2FIC 2RMY 2RND
Enriched GO Terms of Interacting Partners?		Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of Phospholipase C Activity Glomerular Capillary Formation Protein Autophosphorylation Positive Regulation Of DNA Replication Metanephric Glomerulus Vasculature Development Positive Regulation Of Phospholipase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Peptidyl-tyrosine Phosphorylation Metanephric Glomerulus Development Glomerulus Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Retina Vasculature Development In Camera-type Eye Glomerulus Vasculature Development Cardiac Myofibril Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Platelet-derived Growth Factor Regulation Of Kinase Activity Digestive System Development Regulation Of Reactive Oxygen Species Metabolic Process Vascular Endothelial Growth Factor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Adrenal Gland Development Metanephric Nephron Development Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity	Regulation Of Signaling Endocytosis Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Regulation Of ERBB Signaling Pathway Neurogenesis Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signal Transduction Axon Guidance Neuron Differentiation Neuron Development Nervous System Development Vesicle-mediated Transport Chemotaxis Signaling Neuron Projection Development Locomotion Cell Communication Anatomical Structure Morphogenesis Cell Morphogenesis Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Negative Regulation Of Signaling Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Cell Development Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Blood Coagulation
Tagcloud ?			a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Difference) ?			a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Intersection) ?