SNX4 and AGK

Number of citations of the paper that reports this interaction (PubMedID 28712724)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SNX4	AGK
Description		sorting nexin 4	acylglycerol kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Mitochondrial Membrane TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Nucleotide Binding Lipid Kinase Activity Ceramide Kinase Activity ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Sphingosine Kinase Activity Kinase Activity Transferase Activity Acylglycerol Kinase Activity
	Biological Process	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly	Lipid Metabolic Process Protein Insertion Into Mitochondrial Inner Membrane Glycerolipid Metabolic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Lipid Phosphorylation
Pathways			Glycerophospholipid biosynthesis Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)	Mood disorder and prion disease ( 25897833) Psoriasis ( 31376382)
Interacting Genes		18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H	3 interacting genes: HCK PDLIM1 SNX4
Entrez ID		8723	55750
HPRD ID		09334	08554
Ensembl ID		ENSG00000114520	ENSG00000006530
Uniprot IDs		O95219	A0A3B3ISZ0 A4D1U5 Q53H12
PDB IDs			7CGP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development	Respiratory Burst After Phagocytosis Leukocyte Migration Involved In Immune Response Regulation Of Organelle Assembly Leptin Receptor Binding Positive Regulation Of Histamine Secretion By Mast Cell Establishment Or Maintenance Of Actin Cytoskeleton Polarity Type II Interferon-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Cellular Component Biogenesis Lipid Binding Respiratory Burst Involved In Defense Response Focal Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Respiratory Burst Regulation Of Inflammatory Response Positive Regulation Of Organelle Organization Positive Regulation Of Defense Response Regulation Of Vesicle-mediated Transport Cytoplasmic Dynein Complex Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly Transferrin Receptor Binding Insulin Receptor Binding Positive Regulation Of Mast Cell Degranulation Presynaptic Endosome Muscle Alpha-actinin Binding Maintenance Of Cell Polarity Cadherin Binding Involved In Cell-cell Adhesion Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fibroblast Migration Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Vacuole Organization Filamentous Actin Regulation Of Mast Cell Degranulation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Phosphotyrosine Residue Binding Regulation Of Defense Response Cell Adhesion Cell Migration Leukocyte Degranulation Positive Regulation Of Actin Filament Polymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Lipopolysaccharide-mediated Signaling Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Regulation Of Autophagosome Assembly Phosphatidylinositol-3-phosphate Binding
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