SNX4 and ATP6V0A1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (cross-linking study, two hybrid)

		SNX4	ATP6V0A1
Description		sorting nexin 4	ATPase H+ transporting V0 subunit a1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Clathrin-coated Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Melanosome Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H	8 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 TTC3 ZNF267
Entrez ID		8723	535
HPRD ID		09334	01886
Ensembl ID		ENSG00000114520	ENSG00000033627
Uniprot IDs		O95219	A0A994J3Z0 A0A994J3Z4 A0A994J3Z9 B7Z2A9 B7Z641 K7EN36 K7ENA1 K7ERA6 Q53ET5 Q53X12 Q93050
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
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