SNX4 and SUPT5H

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SNX4	SUPT5H
Gene Name		sorting nexin 4	suppressor of Ty 5 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane Extrinsic Component Of Membrane SNARE Complex Early Endosome Membrane Protein Complex	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Chromatin Binding Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Protein Transport Vesicle Organization Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Cell Cycle Response To Organic Substance Gene Expression Viral Process Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat mRNA Capping HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AGK ARL6IP1 ATP6V0A1 BIN1 EGFR HIVEP1 INSR LEPR MAGEA6 PDGFRA PDGFRB PTPN5 SNX2 SNX6 SUPT5H	37 interactors: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CSNK2A1 DBN1 DCAF6 GTF3C1 H2AFX HTATSF1 IK IKBKG LMAN2 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUPT4H1 TERF1 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		8723	6829
HPRD ID		09334	03655
Ensembl ID		ENSG00000114520	ENSG00000196235
Uniprot IDs		O95219	O00267
PDB IDs			2DO3 2E6Z 2E70 3H7H 4L1U
Enriched GO Terms of Interacting Partners?		Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of Phospholipase C Activity Glomerular Capillary Formation Protein Autophosphorylation Positive Regulation Of DNA Replication Metanephric Glomerulus Vasculature Development Positive Regulation Of Phospholipase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Peptidyl-tyrosine Phosphorylation Metanephric Glomerulus Development Glomerulus Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Retina Vasculature Development In Camera-type Eye Glomerulus Vasculature Development Cardiac Myofibril Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Platelet-derived Growth Factor Regulation Of Kinase Activity Digestive System Development Regulation Of Reactive Oxygen Species Metabolic Process Vascular Endothelial Growth Factor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Adrenal Gland Development Metanephric Nephron Development Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity	Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Cellular Macromolecule Biosynthetic Process Regulation Of Viral Transcription Macromolecule Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription From RNA Polymerase II Promoter Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Metabolic Process Cell Cycle Cellular Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Negative Regulation Of Gene Expression, Epigenetic Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter
Tagcloud ?			19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Difference) ?			19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Intersection) ?