NFIL3

Name	nuclear factor, interleukin 3 regulated
Structure
Interactors	18 interactors: AMOTL2 BATF CFTR CREB3 DDIT3 DELEC1 DNMT3L DR1 FHL1 GMCL1 HSF2BP MAFF MAFG PDE9A PIH1D2 RINT1 TRAF2 UBR5
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Natural Killer Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Interleukin-4
GWAS	Bipolar disorder (inflammation and infection response interaction) ( 25781172 ) Birth weight ( 31043758 ) Inflammatory bowel disease ( 23128233 ) Offspring birth weight ( 31043758 )
Entrez ID	4783
HPRD ID	05619
Ensembl ID	ENSG00000165030
Uniprot IDs	Q16649
PDB IDs	8K86 8K89 8K8A
GO Terms Enriched among Interactors ?	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling CAMP Response Element Binding Protein Binding Response To Endoplasmic Reticulum Stress Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Male Meiosis I Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress DNA Damage Response DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of Deacetylase Activity Meiosis I Positive Regulation Of Gene Expression Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of DNA-templated Transcription Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of DNA-templated Transcription Endoplasmic Reticulum Unfolded Protein Response CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II CHOP-ATF4 Complex Intracellular Signal Transduction CHOP-ATF3 Complex Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diaphragm Contraction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Migration Negative Cofactor 2 Complex General Transcription Initiation Factor Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Epidermis Development Sequence-specific Double-stranded DNA Binding Regulation Of Epidermal Cell Differentiation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Meiosis I Cell Cycle Process