GTSE1 and CTTN

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		GTSE1	CTTN
Description		G2 and S-phase expressed 1	cortactin
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding
	Biological Process	Microtubule-based Process DNA Damage Response, Signal Transduction By P53 Class Mediator	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		G2/M Checkpoints The role of GTSE1 in G2/M progression after G2 checkpoint	RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Interacting Genes		22 interacting genes: AKAP9 CASK CPSF7 CTTN FXR2 GGA1 HNRNPD KAT5 KIFAP3 MAPRE1 MAPRE2 MAPRE3 NIN PHF5A PPIE PRPF39 RBM10 TRNAU1AP UBC WDR83 WEE2-AS1 WTAP	58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3
Entrez ID		51512	2017
HPRD ID		09593	01268
Ensembl ID		ENSG00000075218	ENSG00000085733
Uniprot IDs		Q9NYZ3	Q14247 Q53HG7
PDB IDs		6QNN 6QNP	1X69 2D1X
Enriched GO Terms of Interacting Partners?		MRNA Processing Protein Localization To Microtubule Cytoplasmic Microtubule RNA Splicing Microtubule Plus-end Microtubule Plus-end Binding Spindle Midzone Mitotic Spindle Astral Microtubule End RNA Processing MRNA Metabolic Process Microtubule Organizing Center Regulation Of Microtubule Polymerization Or Depolymerization Pre-mRNA 5'-splice Site Binding Mitotic Spindle Pole Microtubule Cytoskeleton Organization Protein Localization To Cytoskeleton Microtubule-based Process MRNA 5'-splice Site Recognition Positive Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization RNA Binding Nucleic Acid Binding Regulation Of Microtubule Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cytoskeleton Organization Positive Regulation Of Protein Polymerization Intracellular Protein Localization RNA Metabolic Process Spindle Assembly Muscle Cell Apoptotic Process U1 SnRNP MRNA Binding Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Regulation Of Microtubule-based Process Cellular Component Assembly Positive Regulation Of Organelle Organization Membraneless Organelle Assembly Protein Serine/threonine Kinase Binding Regulation Of Cytoskeleton Organization Nucleic Acid Metabolic Process Regulation Of Organelle Organization Nucleobase-containing Compound Metabolic Process Microtubule Nucleation Regulation Of MRNA Metabolic Process Positive Regulation Of Microtubule Polymerization Centrosome Localization MRNA Splice Site Recognition Microtubule	SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization
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