GTSE1 and WTAP

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		GTSE1	WTAP
Description		G2 and S-phase expressed 1	WT1 associated protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Identical Protein Binding
	Biological Process	Microtubule-based Process DNA Damage Response, Signal Transduction By P53 Class Mediator	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Modification
Pathways		G2/M Checkpoints The role of GTSE1 in G2/M progression after G2 checkpoint	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS			Erosive tooth wear (severe vs non-severe) ( 29898447) Iron status biomarkers ( 19084217)
Interacting Genes		22 interacting genes: AKAP9 CASK CPSF7 CTTN FXR2 GGA1 HNRNPD KAT5 KIFAP3 MAPRE1 MAPRE2 MAPRE3 NIN PHF5A PPIE PRPF39 RBM10 TRNAU1AP UBC WDR83 WEE2-AS1 WTAP	19 interacting genes: ABHD15 BYSL CPNE1 EIF4ENIF1 EXOSC4 GTSE1 MAGEA11 OGT PSMA1 SLIRP SNCA TAB1 TCF12 TNIP1 VPS52 WT1 YWHAQ ZNF239 ZNF572
Entrez ID		51512	9589
HPRD ID		09593	09259
Ensembl ID		ENSG00000075218	ENSG00000146457
Uniprot IDs		Q9NYZ3	A0A087X1R4 Q15007
PDB IDs		6QNN 6QNP	7VF2 7VF5 7YFJ 7YG4
Enriched GO Terms of Interacting Partners?		MRNA Processing Protein Localization To Microtubule Cytoplasmic Microtubule RNA Splicing Microtubule Plus-end Microtubule Plus-end Binding Spindle Midzone Mitotic Spindle Astral Microtubule End RNA Processing MRNA Metabolic Process Microtubule Organizing Center Regulation Of Microtubule Polymerization Or Depolymerization Pre-mRNA 5'-splice Site Binding Mitotic Spindle Pole Microtubule Cytoskeleton Organization Protein Localization To Cytoskeleton Microtubule-based Process MRNA 5'-splice Site Recognition Positive Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization RNA Binding Nucleic Acid Binding Regulation Of Microtubule Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cytoskeleton Organization Positive Regulation Of Protein Polymerization Intracellular Protein Localization RNA Metabolic Process Spindle Assembly Muscle Cell Apoptotic Process U1 SnRNP MRNA Binding Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Regulation Of Microtubule-based Process Cellular Component Assembly Positive Regulation Of Organelle Organization Membraneless Organelle Assembly Protein Serine/threonine Kinase Binding Regulation Of Cytoskeleton Organization Nucleic Acid Metabolic Process Regulation Of Organelle Organization Nucleobase-containing Compound Metabolic Process Microtubule Nucleation Regulation Of MRNA Metabolic Process Positive Regulation Of Microtubule Polymerization Centrosome Localization MRNA Splice Site Recognition Microtubule	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Cytoplasm Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Ectodermal Digestive Tract Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catabolic Process Negative Regulation Of Translation Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Short-chain Carboxylesterase Activity Regulation Of Neuron Differentiation Positive Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process
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