HIKESHI and OTX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIKESHI	OTX2
Description		heat shock protein nuclear import factor hikeshi	orthodenticle homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Nuclear Speck	Chromatin Nucleus Growth Cone Protein-containing Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Import Into Nucleus Golgi Organization Protein Transport Lung Development Cellular Response To Heat	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways		Regulation of HSF1-mediated heat shock response	Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS			Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ABLIM3 APP OTX2	44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1
Entrez ID		51501	5015
HPRD ID		13701	07190
Ensembl ID		ENSG00000149196	ENSG00000165588
Uniprot IDs		Q53FT3	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs		3WVZ 3WW0
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Lipoprotein Particle Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Establishment Of Protein Localization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of RNA Metabolic Process Axon Choice Point Recognition Positive Regulation Of Gastrulation Heparan Sulfate Binding Signaling Receptor Activator Activity Eukaryotic Initiation Factor 4E Binding Peptidase Activator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Primitive Streak Formation	Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II
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