TRIAP1 and APAF1

Number of citations of the paper that reports this interaction (PMID 15735003)
9

Data Source:
HPRD (in vitro, in vivo)

		TRIAP1	APAF1
Gene Name		TP53 regulated inhibitor of apoptosis 1	apoptotic peptidase activating factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Intermembrane Space Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Protein Binding Phosphatidic Acid Transporter Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs			Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS		Insulin resistance/response ( 21901158)
Protein-Protein Interactions		4 interactors: AMY2A APAF1 HSPA1A TP53	18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1
Entrez ID		51499	317
HPRD ID		13698	03755
Ensembl ID		ENSG00000170855	ENSG00000120868
Uniprot IDs		O43715	O14727
PDB IDs			1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Response To Biotic Stimulus Response To G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Growth Negative Regulation Of Macromitophagy Cellular Heat Acclimation Oligodendrocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Negative Regulation Of Helicase Activity Negative Regulation Of Growth Polysaccharide Digestion Regulation Of Apoptotic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Regulation Of Cell Death Mitochondrial DNA Repair Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Apoptotic Signaling Pathway Regulation Of Cell Growth Regulation Of Apoptotic DNA Fragmentation Oxidative Stress-induced Premature Senescence Negative Regulation Of Inclusion Body Assembly ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Response To Oxidative Stress Regulation Of Cellular Component Organization Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Mitochondrial DNA Metabolic Process	Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress
Tagcloud ?		cardiolipin cl conferred cytochrome ensures excess exert exogenously extrinsic facilitates glycerophospholipid highlight impairs ims inner intermembrane intrinsic mitochondria mitochondrial orchestrates p53csv pa phosphatidic phosphatidylglycerol preli renders space supply vulnerable	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Difference) ?		cardiolipin cl conferred cytochrome ensures excess exert exogenously extrinsic facilitates glycerophospholipid highlight impairs ims inner intermembrane intrinsic mitochondria mitochondrial orchestrates p53csv pa phosphatidic phosphatidylglycerol preli renders space supply vulnerable	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Intersection) ?