TRIAP1 and LCN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIAP1	LCN2
Description		TP53 regulated inhibitor of apoptosis 1	lipocalin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	P53 Binding Protein Binding Phosphatidic Acid Transfer Activity	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding
	Biological Process	Lipid Transport Apoptotic Process Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To UV Negative Regulation Of Apoptotic Process Phospholipid Translocation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Intermembrane Lipid Transfer Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Mitochondrial protein degradation	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs			Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Insulin resistance/response ( 21901158) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		6 interacting genes: AMY2A APAF1 HSPA1A LCN2 PLEKHF2 TP53	62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		51499	3934
HPRD ID		13698	02551
Ensembl ID		ENSG00000170855	ENSG00000148346
Uniprot IDs		O43715	P80188
PDB IDs		4XZS 4XZV 6I3V 6I3Y 6I4Y 8AG0	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Disordered Domain Specific Binding Response To X-ray Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Heat Shock Protein Binding Response To Oxygen Levels Apoptotic Signaling Pathway Response To G1 DNA Damage Checkpoint Signaling Response To Decreased Oxygen Levels Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Alpha-amylase Activity Carbohydrate Catabolic Process Positive Regulation Of Programmed Cell Death Apoptosome Response To Nutrient Levels Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Ficolin-1-rich Granule Lumen Denatured Protein Binding Lysosomal Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Histone Deacetylase Binding Positive Regulation Of Iron Ion Import Across Plasma Membrane Siderophore Transport Protease Binding Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate	Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A
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