TRIAP1

Description		TP53 regulated inhibitor of apoptosis 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Protein-containing Complex
	Molecular Function	P53 Binding Protein Binding Phosphatidic Acid Transfer Activity
	Biological Process	Lipid Transport Apoptotic Process Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To UV Negative Regulation Of Apoptotic Process Phospholipid Translocation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Intermembrane Lipid Transfer Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Mitochondrial protein degradation
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Insulin resistance/response ( 21901158) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Novel Interacting Genes		1 novel interacting genes: SBNO1
Interacting Genes		6 interacting genes: AMY2A APAF1 HSPA1A LCN2 PLEKHF2 TP53
Entrez ID		51499
HPRD ID		13698
Ensembl ID		ENSG00000170855
Uniprot IDs		O43715
PDB IDs		4XZS 4XZV 6I3V 6I3Y 6I4Y 8AG0
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Disordered Domain Specific Binding Response To X-ray Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Heat Shock Protein Binding Response To Oxygen Levels Apoptotic Signaling Pathway Response To G1 DNA Damage Checkpoint Signaling Response To Decreased Oxygen Levels Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Alpha-amylase Activity Carbohydrate Catabolic Process Positive Regulation Of Programmed Cell Death Apoptosome Response To Nutrient Levels Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Ficolin-1-rich Granule Lumen Denatured Protein Binding Lysosomal Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Histone Deacetylase Binding Positive Regulation Of Iron Ion Import Across Plasma Membrane Siderophore Transport Protease Binding Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate
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