TRIAP1 and AMY2A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TRIAP1	AMY2A
Description		TP53 regulated inhibitor of apoptosis 1	amylase alpha 2A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Protein-containing Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	P53 Binding Protein Binding Phosphatidic Acid Transfer Activity	Catalytic Activity Alpha-amylase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Chloride Ion Binding Cation Binding Metal Ion Binding
	Biological Process	Lipid Transport Apoptotic Process Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To UV Negative Regulation Of Apoptotic Process Phospholipid Translocation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Intermembrane Lipid Transfer Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport	Carbohydrate Metabolic Process Carbohydrate Catabolic Process Polysaccharide Digestion
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Mitochondrial protein degradation	Digestion of dietary carbohydrate Developmental Lineage of Pancreatic Acinar Cells
Drugs			Acarbose Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranoside Beta-D-Glucose 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose Pidolic acid 5-Hydroxymethyl-Chonduritol 4,6-dideoxy-4-amino-alpha-D-glucose 6)-Alpha-L-Threo-Hexopyranose alpha-D-quinovopyranose Acarbose Derived Hexasaccharide 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose 4)HEXOPYRANOSE
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Insulin resistance/response ( 21901158) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		6 interacting genes: AMY2A APAF1 HSPA1A LCN2 PLEKHF2 TP53	3 interacting genes: GP2 IGF1R TRIAP1
Entrez ID		51499	279
HPRD ID		13698	00094
Ensembl ID		ENSG00000170855	ENSG00000243480
Uniprot IDs		O43715	P04746 Q53F26
PDB IDs		4XZS 4XZV 6I3V 6I3Y 6I4Y 8AG0	1B2Y 1BSI 1CPU 1HNY 1KB3 1KBB 1KBK 1KGU 1KGW 1KGX 1U2Y 1U30 1U33 1XCW 1XCX 1XD0 1XD1 1XGZ 1XH0 1XH1 1XH2 2CPU 2QMK 2QV4 3BAI 3BAJ 3BAK 3BAW 3BAX 3BAY 3CPU 3IJ7 3IJ8 3IJ9 3OLD 3OLE 3OLG 3OLI 4GQQ 4GQR 4W93 4X9Y 5E0F 5EMY 5KEZ 5TD4 5U3A 5VA9 6OBX 6OCN 6Z8L
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Disordered Domain Specific Binding Response To X-ray Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Heat Shock Protein Binding Response To Oxygen Levels Apoptotic Signaling Pathway Response To G1 DNA Damage Checkpoint Signaling Response To Decreased Oxygen Levels Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Alpha-amylase Activity Carbohydrate Catabolic Process Positive Regulation Of Programmed Cell Death Apoptosome Response To Nutrient Levels Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Ficolin-1-rich Granule Lumen Denatured Protein Binding Lysosomal Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Histone Deacetylase Binding Positive Regulation Of Iron Ion Import Across Plasma Membrane Siderophore Transport Protease Binding Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate	Transcytosis Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin Receptor Activity Insulin Binding Phosphatidic Acid Transfer Activity Zymogen Granule Membrane Phosphatidylinositol 3-kinase Binding Peptidyl-tyrosine Autophosphorylation Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Dendritic Spine Maintenance Insulin Receptor Substrate Binding Protein Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Positive Regulation Of Phospholipid Transport Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Insulin Receptor Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Amyloid-beta Clearance
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