NELFCD and GSTM4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NELFCD	GSTM4
Description		negative elongation factor complex member C/D	glutathione S-transferase mu 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane NELF Complex	Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Protein Binding Transferase Activity Lyase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Lipid Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Glutathione conjugation Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Drugs			Glutathione Glutathione sulfonic acid S-octylglutathione Glutathione disulfide gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine Deoxycholic acid 1-Hydroxy-2-S-glutathionyl-3-para-nitrophenoxy-propane S-Hexylglutathione
Diseases
GWAS		Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 27863252)	Alcohol dependence ( 33290381) Seasonality and depression ( 30217971)
Interacting Genes		21 interacting genes: AAMP AR ARAF ARPC4 CACNA1A CDSN DNAJA1 ENDOV EPRS1 FRMD5 GSTM4 HDAC11 MTA1 NELFA OGT PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638	10 interacting genes: APLP1 GSTM3 IGSF21 LRIF1 MED31 NELFCD TLE1 TP53 UNC119 ZBTB16
Entrez ID		51497	2948
HPRD ID		16096	00706
Ensembl ID		ENSG00000101158	ENSG00000168765
Uniprot IDs		H0UI80 Q8IXH7	A0A140VKE3 A6NNT0 Q03013
PDB IDs		5L3X 6GML 7PKS 7YCX 8JJ6 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 9J0N 9J0O 9J0P	4GTU
Enriched GO Terms of Interacting Partners?		Prostate Gland Growth Regulation Of Protein Ubiquitination Endothelial Cell Activation Circadian Regulation Of Gene Expression Seminiferous Tubule Development Positive Regulation Of RNA Metabolic Process Regulation Of Post-translational Protein Modification Rhythmic Process Cytosol Prostate Induction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Androgen Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Modification Process Regulation Of TOR Signaling Negative Regulation Of Cornification Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Circadian Rhythm Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway DNA Endonuclease Activity, Producing 5'-phosphomonoesters Regulation Of Ubiquitin-dependent Protein Catabolic Process Enzyme Binding	Cellular Response To Norepinephrine Stimulus Alpha-2B Adrenergic Receptor Binding Regulation Of Primary Metabolic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Response To Norepinephrine System Development Central Nervous System Development Identical Protein Binding Developmental Process Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Establishment Of Blood-nerve Barrier Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Transcription Repressor Complex Oxidative Stress-induced Premature Senescence Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition PML Body Glucose Catabolic Process To Lactate Via Pyruvate Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Fibroblast Proliferation Germ Cell Nucleus Cellular Response To Actinomycin D Negative Regulation Of Fibroblast Proliferation Regulation Of Transcription Initiation By RNA Polymerase II Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation NELF Complex Regulation Of Macromolecule Metabolic Process Nuclear Matrix Alpha-2A Adrenergic Receptor Binding Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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