NELFCD and HDAC11

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NELFCD	HDAC11
Gene Name		negative elongation factor complex member C/D	histone deacetylase 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Membrane NELF Complex	Histone Deacetylase Complex Nucleus Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Oligodendrocyte Development Chromatin Modification Histone Deacetylation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		19 interactors: AAMP AR ARAF ARPC4 CACNA1A DNAJA1 ENDOV EPRS FRMD5 GSTM4 HDAC11 MTA1 NELFA PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638	5 interactors: CDKN1A HDAC6 MAPK6 NELFCD PHYHIP
Entrez ID		51497	79885
HPRD ID		16096	09146
Ensembl ID		ENSG00000101158	ENSG00000163517
Uniprot IDs		H0UI80 Q8IXH7	B5MCQ6 E7ETT9 Q96DB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Androgen Receptor Signaling Pathway Endothelial Cell Activation Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Growth Regulation Of Protein Ubiquitination Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Negative Regulation Of Integrin Biosynthetic Process Cerebellar Molecular Layer Development Sperm Entry Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Cellular Metabolic Process Prostate Gland Development Heterocycle Metabolic Process Biosynthetic Process Prolyl-tRNA Aminoacylation Vestibular Nucleus Development Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Protein Autoubiquitination Regulation Of Establishment Of Protein Localization Rhythmic Process Circadian Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Cerebellum Maturation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Musculoskeletal Movement, Spinal Reflex Action Regulation Of Protein Autoubiquitination NK T Cell Differentiation Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly	Cellular Response To Heat Response To Heat Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Response To Toxic Substance Response To Temperature Stimulus Cellular Response To Extracellular Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Intestinal Epithelial Cell Maturation Aggresome Assembly Cellular Response To UV-B Tubulin Deacetylation Positive Regulation Of Oxidative Stress-induced Cell Death Peptidyl-lysine Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Receptor Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Stress-induced Premature Senescence Response To Misfolded Protein Regulation Of Hydrogen Peroxide-induced Cell Death Response To Extracellular Stimulus Misfolded Or Incompletely Synthesized Protein Catabolic Process Regulation Of Microtubule-based Movement Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Arrest Regulation Of Receptor Biosynthetic Process Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Import Into Nucleus, Translocation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Androgen Receptor Signaling Pathway Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Histone H4 Deacetylation Negative Regulation Of Oxidoreductase Activity Response To Arsenic-containing Substance Regulation Of Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Senescence Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Microtubule Depolymerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Tagcloud ?			acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Difference) ?			acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Intersection) ?