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PDE6H and GNAO1
Number of citations of the paper that reports this interaction (PMID
15215290
)
17
Data Source:
HPRD
(two hybrid)
PDE6H
GNAO1
Gene Name
phosphodiesterase 6H, cGMP-specific, cone, gamma
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Neuron Projection
Molecular Function
Enzyme Inhibitor Activity
CGMP Binding
3',5'-cyclic-GMP Phosphodiesterase Activity
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
G-protein Coupled Serotonin Receptor Binding
Mu-type Opioid Receptor Binding
GTPase Activating Protein Binding
Metal Ion Binding
Corticotropin-releasing Hormone Receptor 1 Binding
Biological Process
Activation Of MAPK Activity
Visual Perception
Metabolic Process
Negative Regulation Of Catalytic Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Response To Stimulus
Muscle Contraction
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Aging
Locomotory Behavior
Regulation Of Heart Contraction
Forebrain Development
Neuron Projection Development
Response To Cytokine
Response To Drug
Response To Hydrogen Peroxide
Response To Morphine
Positive Regulation Of GTPase Activity
Negative Regulation Of Calcium Ion Transport
Pathways
Signaling by GPCR
Ca2+ pathway
PLC beta mediated events
G-protein activation
Opioid Signalling
Signaling by Wnt
G-protein mediated events
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
AGTR1
APP
COTL1
GNAO1
34 interactors:
ADORA1
ADRA2A
ADRA2C
CACNA1B
CCR5
CRHR1
DCTN2
FFAR2
GABBR1
GNAI1
GPSM2
GRM6
HRH4
KLHL3
NGB
NUCB1
OPRD1
OPRM1
PDE6G
PDE6H
PTPRU
RGS1
RGS10
RGS14
RGS16
RGS19
RGS20
RGS4
RGS5
RGS7
RIC8A
S1PR5
SCN8A
TSHR
Entrez ID
5149
2775
HPRD ID
03116
00757
Ensembl ID
ENSG00000139053
ENSG00000087258
Uniprot IDs
Q13956
B3KP89
P09471
Q6AWC5
Q8N6I9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Hydrolase Activity
Collateral Sprouting In Absence Of Injury
Positive Regulation Of NAD(P)H Oxidase Activity
Locomotory Behavior
Renin-angiotensin Regulation Of Aldosterone Production
Collateral Sprouting
Axon Midline Choice Point Recognition
Positive Regulation Of Phospholipase A2 Activity
Regulation Of Blood Vessel Size By Renin-angiotensin
Cellular Calcium Ion Homeostasis
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Calcium Ion Homeostasis
Positive Regulation Of Catalytic Activity
Axon Choice Point Recognition
Regulation Of NAD(P)H Oxidase Activity
Angiotensin-activated Signaling Pathway
Neuron Remodeling
Positive Regulation Of Cholesterol Esterification
Cellular Metal Ion Homeostasis
Response To External Stimulus
Regulation Of Cholesterol Esterification
Response To Oxidative Stress
Regulation Of Phospholipase A2 Activity
Low-density Lipoprotein Particle Remodeling
Cellular Cation Homeostasis
Forebrain Development
Regulation Of Blood Volume By Renin-angiotensin
Cellular Ion Homeostasis
Metal Ion Homeostasis
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Cellular Chemical Homeostasis
Cellular Copper Ion Homeostasis
Ion Homeostasis
Regulation Of Renal Sodium Excretion
Behavior
Chemotaxis
Copper Ion Homeostasis
Suckling Behavior
Regulation Of Catalytic Activity
Regulation Of Growth
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Regulation Of Excretion
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Plasma Lipoprotein Particle Remodeling
Defense Response To Fungus
Positive Regulation Of Steroid Metabolic Process
Cellular Homeostasis
Neuron Maturation
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Termination Of G-protein Coupled Receptor Signaling Pathway
Termination Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Signaling
Regulation Of Signaling
Positive Regulation Of ERBB Signaling Pathway
Signaling
Cell Communication
Signal Transduction
Cell-cell Signaling
Neurological System Process
Regulation Of Signal Transduction
Locomotory Behavior
Positive Regulation Of GTPase Activity
Negative Regulation Of Epinephrine Secretion
Regulation Of Sensory Perception Of Pain
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Behavior
Regulation Of ERBB Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of Signal Transduction
Response To Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Cellular Response To Stimulus
Regulation Of Cellular Process
Positive Regulation Of Hydrolase Activity
Sensory Perception
Regulation Of Neurological System Process
Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Smooth Muscle Contraction
Regulation Of Ion Transport
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Hormone Secretion
Negative Regulation Of Uterine Smooth Muscle Contraction
Regulation Of Cyclase Activity
Single-organism Behavior
Regulation Of MAP Kinase Activity
Negative Regulation Of Secretion By Cell
Tagcloud
?
aberrations
assessing
associations
catenin
clinicopathological
egfr
gnai2
gnaq
gnas
grades
impacts
intraductal
ipmn
ipmns
kras
morphological
mucinous
mutations
neoplasm
overexpression
pakt
pancreas
papillary
phenotypes
pik3ca
pmapk
retrospectively
smad4
tp53
Tagcloud (Difference)
?
aberrations
assessing
associations
catenin
clinicopathological
egfr
gnai2
gnaq
gnas
grades
impacts
intraductal
ipmn
ipmns
kras
morphological
mucinous
mutations
neoplasm
overexpression
pakt
pancreas
papillary
phenotypes
pik3ca
pmapk
retrospectively
smad4
tp53
Tagcloud (Intersection)
?