PDE6H and AGTR1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDE6H	AGTR1
Gene Name		phosphodiesterase 6H, cGMP-specific, cone, gamma	angiotensin II receptor, type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Enzyme Inhibitor Activity CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Angiotensin Type I Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stimulus	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Vasodilation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Valsartan Olmesartan Losartan Candesartan Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan Azilsartan medoxomil
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AGTR1 APP COTL1 GNAO1	20 interactors: ADRBK1 ADRBK2 AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 RAB5A RAF1 THOP1 ZBTB16
Entrez ID		5149	185
HPRD ID		03116	00107
Ensembl ID		ENSG00000139053	ENSG00000144891
Uniprot IDs		Q13956	D3DNG8 P30556 Q53YY0 Q6NUP5 Q8TBK4
PDB IDs			1ZV0
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Angiotensin-activated Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hydrolase Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of NAD(P)H Oxidase Activity Locomotory Behavior Renin-angiotensin Regulation Of Aldosterone Production Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Phospholipase A2 Activity Regulation Of Blood Vessel Size By Renin-angiotensin Cellular Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Regulation Of NAD(P)H Oxidase Activity Angiotensin-activated Signaling Pathway Neuron Remodeling Positive Regulation Of Cholesterol Esterification Cellular Metal Ion Homeostasis Response To External Stimulus Regulation Of Cholesterol Esterification Response To Oxidative Stress Regulation Of Phospholipase A2 Activity Low-density Lipoprotein Particle Remodeling Cellular Cation Homeostasis Forebrain Development Regulation Of Blood Volume By Renin-angiotensin Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Chemical Homeostasis Cellular Copper Ion Homeostasis Ion Homeostasis Regulation Of Renal Sodium Excretion Behavior Chemotaxis Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Excretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Plasma Lipoprotein Particle Remodeling Defense Response To Fungus Positive Regulation Of Steroid Metabolic Process Cellular Homeostasis Neuron Maturation	Regulation Of Signaling Positive Regulation Of MAPK Cascade Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Receptor Internalization Negative Regulation Of Signaling Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Negative Regulation Of Cell Death Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phosphorylation Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transport Activation Of Phospholipase C Activity Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration
Tagcloud ?			125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Difference) ?			125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Intersection) ?