PDE6H

Description		phosphodiesterase 6H
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Visual Perception Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs		Sildenafil Vardenafil
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Interacting Genes		6 interacting genes: AGTR1 APP COTL1 GNAO1 POU6F2 PRKAB2
Entrez ID		5149
HPRD ID		03116
Ensembl ID		ENSG00000139053
Uniprot IDs		Q13956
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Circulation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Regulation Of System Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production System Process Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Fungus Response To Fungus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Binding Site Of Polarized Growth G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Small Molecule Metabolic Process Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Positive Regulation Of Inflammatory Response Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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