VCX2 and THAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VCX2	THAP1
Description		variable charge X-linked 2	THAP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Brain Development	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS			Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		9 interacting genes: BEND7 DDIT4L GSC2 MACROH2A1 MEOX2 PAX6 STAC3 THAP1 ZNF526	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		51480	55145
HPRD ID		06749	15496
Ensembl ID		ENSG00000177504	ENSG00000131931
Uniprot IDs		Q9H322	Q9NVV9
PDB IDs			2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		DNA Binding Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Forebrain-midbrain Boundary Formation Positive Regulation Of Epithelial Cell Differentiation Pancreatic A Cell Development Negative Regulation Of Protein Localization To Chromosome, Telomeric Region RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding ADP-D-ribose Binding Regulation Of NAD Metabolic Process Regulation Of RDNA Heterochromatin Formation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Habenula Development Pallium Development Positive Regulation Of Endodermal Cell Differentiation Positive Regulation Of Response To Oxidative Stress ADP-D-ribose Modification-dependent Protein Binding Sequence-specific Double-stranded DNA Binding Somite Specification Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Formation Of Anatomical Boundary Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Regulation Of Epithelial Cell Differentiation Telencephalon Regionalization Poly-ADP-D-ribose Modification-dependent Protein Binding RDNA Binding Sex Chromatin Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Double-stranded Methylated DNA Binding Barr Body Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Transcription By RNA Polymerase II Type B Pancreatic Cell Differentiation Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Negative Regulation Of Response To Oxidative Stress Establishment Of Protein Localization To Chromatin Regulation Of Heterochromatin Formation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Negative Regulation Of Transcription By RNA Polymerase I	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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