TAOK3 and LRRK2

Number of citations of the paper that reports this interaction (PMID 20949042)
11

Data Source:
BioGRID (enzymatic study)

		TAOK3	LRRK2
Gene Name		TAO kinase 3	leucine-rich repeat kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Inclusion Body Axon Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transferase Activity	SNARE Binding Glycoprotein Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Tubulin Binding Kinase Activity Rho GTPase Binding Syntaxin-1 Binding Clathrin Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Kinase A Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity DNA Repair Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Endocytosis Autophagy Response To Oxidative Stress Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Determination Of Adult Lifespan Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Neuron Death Cellular Response To Manganese Ion Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Regulation Of Neuron Death Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 22438815 21738487)
Protein-Protein Interactions		4 interactors: ATF7 ERN1 LRRK2 TRAF2	33 interactors: ACTB AKT1 ARFGAP1 ARHGEF7 BAG5 DVL1 DVL2 DVL3 EIF4EBP1 HSPD1 L3MBTL3 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MBP PRKCZ PTPN23 RALYL RIPK2 SH3GL1 SH3GL2 SH3GL3 STK24 STK25 STK3 STRBP TAOK3 TRAF2 TUBA1A
Entrez ID		51347	120892
HPRD ID		11620	10613
Ensembl ID		ENSG00000135090	ENSG00000188906
Uniprot IDs		Q9H2K8	Q17RV3 Q5S007
PDB IDs			2ZEJ 3D6T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Binding Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Peptidyl-serine Phosphorylation Positive Regulation Of Binding Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation HAC1-type Intron Splice Site Recognition And Cleavage MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Negative Regulation Of Peroxidase Activity Peptidyl-serine Trans-autophosphorylation Positive Regulation Of Phosphorylation Cellular Response To Inorganic Substance Positive Regulation Of Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Hydrolase Activity Cell Death Death Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Protein Autophosphorylation Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Cellular Response To Dopamine Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Targeting To Mitochondrion Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Kidney Size Regulation Of Phosphorylation Regulation Of Binding Activation Of Protein Kinase Activity Cellular Response To Manganese Ion Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Intracellular Distribution Of Mitochondria Regulation Of Phosphorus Metabolic Process	Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Anatomical Structure Development Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Developmental Process Regulation Of Signaling Activation Of Innate Immune Response
Tagcloud ?			autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Difference) ?			autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Intersection) ?