KIR2DL4

Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Objective response to lithium treatment ( 26503763)
Interacting Genes		9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6
Entrez ID		3805
HPRD ID		16082
Ensembl ID		ENSG00000189013
Uniprot IDs		A0A0B4J1S6 A0A376A929 Q99706
PDB IDs		3WYR
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Mast Cell Apoptotic Process Serotonin Secretion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cytokine Production Involved In Immune Response B Cell Mediated Immunity Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Serotonin Secretion By Platelet Regulation Of Cytokine Production Involved In Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Adaptive Immune Response Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity CD8 Receptor Binding Tolerance Induction Dependent Upon Immune Response Peripheral B Cell Tolerance Induction MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Leukocyte Mediated Immunity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Negative Regulation Of G0 To G1 Transition Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation
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