KIR2DL4 and HLA-G

Number of citations of the paper that reports this interaction (PMID 10190900)
85

Data Source:
HPRD (in vitro, in vivo)

		KIR2DL4	HLA-G
Gene Name		killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	major histocompatibility complex, class I, G
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Golgi Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Receptor Binding Peptide Antigen Binding Protein Homodimerization Activity
	Biological Process	Cellular Defense Response Signal Transduction Regulation Of Immune Response	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Negative Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 22412388) IgE levels ( 22075330) Rheumatoid arthritis ( 21653640)
Protein-Protein Interactions		5 interactors: FCER1G HLA-G RBPMS RNF216 TRIP6	9 interactors: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2
Entrez ID		3805	3135
HPRD ID		16082	00834
Ensembl ID		ENSG00000189013	ENSG00000204632
Uniprot IDs		Q99706	P17693 Q29897 Q31611 Q5RJ85 Q6DU14
PDB IDs			1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Cytokine Production Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Type III Hypersensitivity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Transport Positive Regulation Of Adaptive Immune Response Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Antigen Processing And Presentation Of Peptide Antigen Serotonin Secretion Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Regulatory T Cell Differentiation Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Negative Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Dendritic Cell Differentiation Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Immune System Process Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Cell Activation Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Mast Cell Activation Regulation Of SMAD Protein Import Into Nucleus	Regulation Of Immune System Process Defense Response Cytosol To ER Transport Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Single Organismal Cell-cell Adhesion Viral Process Response To Stress Intracellular Transport Of Virus Immune Response Antigen Processing And Presentation Of Peptide Antigen Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Calcium Ion Transport T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cellular Defense Response Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Cytotoxic T Cell Differentiation Negative Regulation Of Interferon-beta Secretion Lymphocyte Activation Regulation Of Defense Response To Virus Regulation Of T Cell Mediated Cytotoxicity Peptide Transport Negative Regulation Of Ion Transport
Tagcloud ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Difference) ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Intersection) ?