KIR2DL4 and FCER1G

Number of citations of the paper that reports this interaction (PMID 15778339)
27

Data Source:
HPRD (in vivo)

		KIR2DL4	FCER1G
Gene Name		killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Protein Binding IgE Receptor Activity IgE Binding IgG Binding
	Biological Process	Cellular Defense Response Signal Transduction Regulation Of Immune Response	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Protein Localization To Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Platelet Adhesion to exposed collagen FCERI mediated NF-kB activation GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall Innate Immune System
Drugs			Benzylpenicilloyl Polylysine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FCER1G HLA-G RBPMS RNF216 TRIP6	8 interactors: FCER1A FCGR3A GP6 KIR2DL4 LYN NCR1 PLCG2 SYK
Entrez ID		3805	2207
HPRD ID		16082	00916
Ensembl ID		ENSG00000189013	ENSG00000158869
Uniprot IDs		Q99706	P30273
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Cytokine Production Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Type III Hypersensitivity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Transport Positive Regulation Of Adaptive Immune Response Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Antigen Processing And Presentation Of Peptide Antigen Serotonin Secretion Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Regulatory T Cell Differentiation Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Negative Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Dendritic Cell Differentiation Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Immune System Process Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Cell Activation Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Mast Cell Activation Regulation Of SMAD Protein Import Into Nucleus	Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Positive Regulation Of Interleukin-3 Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Mast Cell Activation B Cell Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Response To Stress Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Platelet Activation Immune System Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune Response Serotonin Secretion Phagocytosis Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Ammonium Transport Serotonin Transport Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Immune System Process Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Signaling Leukocyte Activation Regulation Of Platelet Aggregation Cell Communication Regulation Of Exocytosis Leukocyte Activation Involved In Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Body Fluid Levels Immune Response Leukotriene Biosynthetic Process Wound Healing Monoamine Transport
Tagcloud ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Difference) ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Intersection) ?