KIR2DL4 and TRIP6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KIR2DL4	TRIP6
Gene Name		killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	thyroid hormone receptor interactor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Cellular Defense Response Signal Transduction Regulation Of Immune Response	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		5 interactors: FCER1G HLA-G RBPMS RNF216 TRIP6	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		3805	7205
HPRD ID		16082	04242
Ensembl ID		ENSG00000189013	ENSG00000087077
Uniprot IDs		Q99706	F2ZC06 Q15654
PDB IDs			1X61 2DLO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Cytokine Production Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Type III Hypersensitivity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Transport Positive Regulation Of Adaptive Immune Response Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Antigen Processing And Presentation Of Peptide Antigen Serotonin Secretion Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Regulatory T Cell Differentiation Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Negative Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Dendritic Cell Differentiation Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Immune System Process Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Cell Activation Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Mast Cell Activation Regulation Of SMAD Protein Import Into Nucleus	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?