IAPP and COL25A1

Number of citations of the paper that reports this interaction (PubMedID 15522881)
0

Data Source:
HPRD (in vitro)

		IAPP	COL25A1
Description		islet amyloid polypeptide	collagen type XXV alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Inclusion Body Neuronal Cell Body	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Lipid Binding Identical Protein Binding Receptor Ligand Activity	Amyloid-beta Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Sensory Perception Of Pain Osteoclast Differentiation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Amyloid Fibril Formation	Axonogenesis Involved In Innervation
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation	Collagen degradation Collagen biosynthesis and modifying enzymes Collagen chain trimerization
Drugs		Copper
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Body mass index ( 25133637) Carotid plaque burden ( 28282560) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Height ( 28552196) Late-onset Alzheimer's disease ( 27770636) Schizophrenia (age at onset) ( 21688384) Systemic lupus erythematosus ( 21408207)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	3 interacting genes: APP IAPP SNCA
Entrez ID		3375	84570
HPRD ID		01005	09886
Ensembl ID		ENSG00000121351	ENSG00000188517
Uniprot IDs		P10997	A0A2R8Y760 A8MWQ5 Q9BXS0
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR 7BG0 7M61 7M62 7M64 7M65 7YKW 7YL0 7YL3 7YL7 8AWT 8AZ0 8AZ1 8AZ2 8AZ3 8AZ4 8AZ5 8AZ6 8AZ7 8F0J 8F0K 8F2A 8F2B 8R4I 8YG2 9GZ6 9GZP 9GZS 9GZT 9GZW 9GZX 9GZY
Enriched GO Terms of Interacting Partners?		Insulin Processing Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Insulin Metabolic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Coreceptor Activity Cellular Response To Acadesine Islet Amyloid Polypeptide Processing Receptor Internalization Calcitonin Gene-related Peptide Binding Endopeptidase Activity Regulation Of Hormone Levels Transport Vesicle Secretory Granule Response To Chlorate Enkephalin Processing Adrenomedullin Binding CGRP Receptor Complex Serine-type Peptidase Activity Response To Hormone Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Serine-type Endopeptidase Activity Adrenomedullin Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Basement Membrane Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Complex Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Receptor-mediated Endocytosis Hormone Metabolic Process Protein Processing Protein Localization To Plasma Membrane Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Receptor Complex Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Transdifferentiation Response To Iron(II) Ion Regulation Of Protein Glycosylation Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Carbohydrate Mediated Signaling Calcium Ion Transport	Amyloid Fibril Formation Protein Complex Oligomerization Regulation Of Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Positive Regulation Of CAMP/PKA Signal Transduction Inclusion Body Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Microglial Cell Activation Response To Copper Ion Regulation Of Supramolecular Fiber Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of CAMP/PKA Signal Transduction Supramolecular Fiber Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Calcium-mediated Signaling Protein Destabilization Cell-cell Signaling Macrophage Activation Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Cell Communication Adult Locomotory Behavior Response To Interleukin-1 Protein Tetramerization Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Apoptotic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Receptor Ligand Activity Myeloid Leukocyte Activation Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Positive Regulation Of Synaptic Transmission
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