IAPP and RAMP2

Number of citations of the paper that reports this interaction (PubMedID 16531504)
0

Data Source:
HPRD (in vitro)

		IAPP	RAMP2
Description		islet amyloid polypeptide	receptor activity modifying protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Inclusion Body Neuronal Cell Body	Cytoplasm Lysosome Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Receptor Complex Adrenomedullin Receptor Complex
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Lipid Binding Identical Protein Binding Receptor Ligand Activity	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Adrenomedullin Binding
	Biological Process	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Sensory Perception Of Pain Osteoclast Differentiation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Amyloid Fibril Formation	Angiogenesis Vasculogenesis Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation	G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Copper	Pramlintide
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	A body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		3375	10266
HPRD ID		01005	05516
Ensembl ID		ENSG00000121351	ENSG00000131477
Uniprot IDs		P10997	O60895
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR 7BG0 7M61 7M62 7M64 7M65 7YKW 7YL0 7YL3 7YL7 8AWT 8AZ0 8AZ1 8AZ2 8AZ3 8AZ4 8AZ5 8AZ6 8AZ7 8F0J 8F0K 8F2A 8F2B 8R4I 8YG2 9GZ6 9GZP 9GZS 9GZT 9GZW 9GZX 9GZY	2XVT 3AQE 3AQF 4RWF 6UUN 6V2E 7TYH 7TYX 7TYY
Enriched GO Terms of Interacting Partners?		Insulin Processing Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Insulin Metabolic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Coreceptor Activity Cellular Response To Acadesine Islet Amyloid Polypeptide Processing Receptor Internalization Calcitonin Gene-related Peptide Binding Endopeptidase Activity Regulation Of Hormone Levels Transport Vesicle Secretory Granule Response To Chlorate Enkephalin Processing Adrenomedullin Binding CGRP Receptor Complex Serine-type Peptidase Activity Response To Hormone Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Serine-type Endopeptidase Activity Adrenomedullin Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Basement Membrane Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Complex Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Receptor-mediated Endocytosis Hormone Metabolic Process Protein Processing Protein Localization To Plasma Membrane Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Receptor Complex Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Transdifferentiation Response To Iron(II) Ion Regulation Of Protein Glycosylation Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Carbohydrate Mediated Signaling Calcium Ion Transport	Calcitonin Family Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Response To Nerve Growth Factor G Protein-coupled Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Nerve Growth Factor Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Myeloid Leukocyte Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Metal Ion Transport Receptor Internalization Regulation Of Osteoclast Differentiation Regulation Of Copper Ion Transmembrane Transport Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Sucrose Stimulus Regulation Of Tissue Remodeling Regulation Of Monoatomic Ion Transport Calcitonin Receptor Binding Cellular Response To Tumor Necrosis Factor Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Adrenomedullin Binding CGRP Receptor Complex Calcitonin Receptor Activity Hormone Activity Negative Regulation Of Hemopoiesis Positive Regulation Of Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Receptor Ligand Activity Response To Tumor Necrosis Factor Positive Regulation Of Programmed Cell Death Amylin Receptor 3 Signaling Pathway Siderophore Transport Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity
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