IAPP and PCSK2

Number of citations of the paper that reports this interaction (PMID 3053705)
24

Data Source:
HPRD (in vivo, in vitro)

		IAPP	PCSK2
Gene Name		islet amyloid polypeptide	proprotein convertase subtilisin/kexin type 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Extracellular Space Membrane Transport Vesicle Dendrite Secretory Granule Lumen Perikaryon
	Molecular Function	Receptor Binding Hormone Activity Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Protein Complex Binding
	Biological Process	Apoptotic Process Signal Transduction Cell-cell Signaling Sensory Perception Of Pain Endocrine Pancreas Development Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption	Proteolysis Nervous System Development Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing Cellular Protein Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR G alpha (s) signalling events GPCR ligand binding Metabolic disorders of biological oxidation enzymes Amyloids GPCR downstream signaling Regulation of beta-cell development Regulation of gene expression in beta cells Calcitonin-like ligand receptors Class B/2 (Secretin family receptors)	Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS			Biochemical measures ( 19260141) Dialysis-related mortality ( 21546767) Menarche (age at onset) ( 21102462) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	3 interactors: IAPP PMCH SCG5
Entrez ID		3375	5126
HPRD ID		01005	01202
Ensembl ID		ENSG00000121351	ENSG00000125851
Uniprot IDs		P10997	P16519
PDB IDs		1KUW 2G48 2KB8 2L86 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Levels Peptide Hormone Processing Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of CAMP Metabolic Process Organ Senescence Peptide Metabolic Process Protein Localization To Plasma Membrane Detection Of Glucose Basement Membrane Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hormone Metabolic Process Response To Chlorate Positive Regulation Of Protein Glycosylation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Plasma Membrane Organization Response To Iron(II) Ion Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Protein Processing Response To Leucine Cellular Amide Metabolic Process Regulation Of Hormone Secretion Insulin Processing Exocrine Pancreas Development Vascular Smooth Muscle Cell Development Calcium Ion Transport Protein Autoprocessing Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Angiogenesis Insulin Metabolic Process Negative Regulation Of Vascular Permeability Receptor-mediated Endocytosis Transdifferentiation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Protein Transport Regulation Of Vasculogenesis Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Protein Secretion	Neuropeptide Signaling Pathway Feeding Behavior Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Behavior Negative Regulation Of Tissue Remodeling Eating Behavior Regulation Of Bone Resorption Cell-cell Signaling Peptide Hormone Processing Regulation Of Bone Remodeling Endocrine Pancreas Development G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		deficient drives metabolic p53 regression reprogramming tumor upregulation	2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Difference) ?		deficient drives metabolic p53 regression reprogramming tumor upregulation	2kd abcc8 antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Intersection) ?