IAPP and RAMP1

Number of citations of the paper that reports this interaction (PMID 10385705)
47

Data Source:
HPRD (in vitro)

		IAPP	RAMP1
Gene Name		islet amyloid polypeptide	receptor (G protein-coupled) activity modifying protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Receptor Binding Hormone Activity Identical Protein Binding	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Coreceptor Activity Calcitonin Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction Cell-cell Signaling Sensory Perception Of Pain Endocrine Pancreas Development Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR G alpha (s) signalling events GPCR ligand binding Metabolic disorders of biological oxidation enzymes Amyloids GPCR downstream signaling Regulation of beta-cell development Regulation of gene expression in beta cells Calcitonin-like ligand receptors Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	6 interactors: CALCA CALCR CALCRL IAPP SLC31A2 VIPR1
Entrez ID		3375	10267
HPRD ID		01005	05515
Ensembl ID		ENSG00000121351	ENSG00000132329
Uniprot IDs		P10997	E9PC20 O60894
PDB IDs		1KUW 2G48 2KB8 2L86 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ	2YX8 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Levels Peptide Hormone Processing Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Enkephalin Processing Islet Amyloid Polypeptide Processing Regulation Of CAMP Metabolic Process Organ Senescence Peptide Metabolic Process Protein Localization To Plasma Membrane Detection Of Glucose Basement Membrane Assembly Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hormone Metabolic Process Response To Chlorate Positive Regulation Of Protein Glycosylation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Plasma Membrane Organization Response To Iron(II) Ion Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Protein Processing Response To Leucine Cellular Amide Metabolic Process Regulation Of Hormone Secretion Insulin Processing Exocrine Pancreas Development Vascular Smooth Muscle Cell Development Calcium Ion Transport Protein Autoprocessing Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Angiogenesis Insulin Metabolic Process Negative Regulation Of Vascular Permeability Receptor-mediated Endocytosis Transdifferentiation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Protein Transport Regulation Of Vasculogenesis Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Protein Secretion	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Internalization Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Bone Resorption Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Regulation Of Bone Remodeling Positive Regulation Of Lyase Activity Receptor-mediated Endocytosis G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Cellular Metal Ion Homeostasis Regulation Of Cyclase Activity Regulation Of Tissue Remodeling Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Sensory Perception Of Pain Feeding Behavior Ion Homeostasis Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Endocytosis Cellular Homeostasis Regulation Of Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signal Transduction Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization
Tagcloud ?		deficient drives metabolic p53 regression reprogramming tumor upregulation	adenylate autoradiography barrier bbb blockers blue calcitonin cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Difference) ?		deficient drives metabolic p53 regression reprogramming tumor upregulation	adenylate autoradiography barrier bbb blockers blue calcitonin cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Intersection) ?