IAPP and PDX1

Number of citations of the paper that reports this interaction (PubMedID 9115263)
0

Data Source:
HPRD (in vitro)

		IAPP	PDX1
Description		islet amyloid polypeptide	pancreatic and duodenal homeobox 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Inclusion Body Neuronal Cell Body	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Lipid Binding Identical Protein Binding Receptor Ligand Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Sensory Perception Of Pain Osteoclast Differentiation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Negative Regulation Of Amyloid Fibril Formation Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Glucose Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Glucose Mediated Signaling Pathway Regulation Of Gene Expression Morphogenesis Of Embryonic Epithelium Insulin Secretion Cell Differentiation Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Vitamin Response To Lipid Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Regulation Of Cell Population Proliferation Glucose Homeostasis Response To L-leucine Response To Alkaloid Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Transdifferentiation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Fatty Acid Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Acadesine Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation	Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs		Copper
Diseases			Permanent neonatal diabetes mellitus (PNDM) Pancreatic agenesis Maturity onset diabetes of the young (MODY)
GWAS		Diisocyanate-induced asthma ( 25918132)	Acute insulin response ( 28490609) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 25086665 26098869 29422604) Peak insulin response ( 28490609)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		3375	3651
HPRD ID		01005	02843
Ensembl ID		ENSG00000121351	ENSG00000139515
Uniprot IDs		P10997	P52945
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR 7BG0 7M61 7M62 7M64 7M65 7YKW 7YL0 7YL3 7YL7 8AWT 8AZ0 8AZ1 8AZ2 8AZ3 8AZ4 8AZ5 8AZ6 8AZ7 8F0J 8F0K 8F2A 8F2B 8R4I 8YG2 9GZ6 9GZP 9GZS 9GZT 9GZW 9GZX 9GZY	6F8F 7KPK
Enriched GO Terms of Interacting Partners?		Insulin Processing Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Insulin Metabolic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Coreceptor Activity Cellular Response To Acadesine Islet Amyloid Polypeptide Processing Receptor Internalization Calcitonin Gene-related Peptide Binding Endopeptidase Activity Regulation Of Hormone Levels Transport Vesicle Secretory Granule Response To Chlorate Enkephalin Processing Adrenomedullin Binding CGRP Receptor Complex Serine-type Peptidase Activity Response To Hormone Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Serine-type Endopeptidase Activity Adrenomedullin Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Basement Membrane Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Complex Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Receptor-mediated Endocytosis Hormone Metabolic Process Protein Processing Protein Localization To Plasma Membrane Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Receptor Complex Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Transdifferentiation Response To Iron(II) Ion Regulation Of Protein Glycosylation Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Carbohydrate Mediated Signaling Calcium Ion Transport	DNA-dependent Protein Kinase Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein-DNA Complex DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Cell Differentiation Leukocyte Differentiation B Cell Lineage Commitment Response To Gamma Radiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding 5'-deoxyribose-5-phosphate Lyase Activity Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of RNA Metabolic Process DNA Recombination U3 SnoRNA Binding Positive Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hormone Secretion Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Telomere Maintenance Hormone Transport Regulation Of Gene Expression V(D)J Recombination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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