CCDC174 and EIF4A3

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (two hybrid, two hybrid, proximity labelling technology, affinity chromatography technology), HPRD (two hybrid)

		CCDC174	EIF4A3
Name		coiled-coil domain containing 174	eukaryotic translation initiation factor 4A3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding
	Biological Process	None	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		None	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
GWAS		Sjögren's syndrome ( 28076899 )	High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Myocardial infarction ( 26708285 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )
Novel Interactors		None recorded	1 novel interactors: CCR6
Interacting Genes		4 interacting genes: ALOX5 EIF4A3 GSK3A NAA10	38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB
Entrez ID		51244	9775
HPRD ID		12820	06482
Ensembl ID		ENSG00000154781	ENSG00000141543
Uniprot IDs		A0A0B4J1R8 Q6PII3	I3L3H2 P38919
PDB IDs		Not available	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
GO Terms Enriched among Interactors		Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein-N-terminal-glutamate Acetyltransferase Activity Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Protein N-terminal-serine Acetyltransferase Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Arachidonate Metabolite Production Involved In Inflammatory Response Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Postsynapse Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Glycogen (starch) Synthase Activity Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion NatA Complex Selenocysteine Insertion Sequence Binding Negative Regulation Of Translational Elongation Regulation Of Translation At Postsynapse Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity Negative Regulation Of Vascular Wound Healing Cellular Response To Interleukin-3 Leukocyte Chemotaxis Involved In Inflammatory Response Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Brain-derived Neurotrophic Factor Stimulus Lipoxygenase Pathway Nuclear Envelope Lumen Cardiac Left Ventricle Morphogenesis Neuronal Cell Body Internal Protein Amino Acid Acetylation Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential	Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding