CCDC174 and NAA10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC174	NAA10
Description		coiled-coil domain containing 174	N-alpha-acetyltransferase 10, NatA catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleolus Cytoplasm Cytosol Membrane NatA Complex
	Molecular Function	Protein Binding	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Protein-N-terminal-alanine Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Ribosome Binding Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity
	Biological Process		Protein Acetylation N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways
Drugs
Diseases
GWAS		Sjögren's syndrome ( 28076899)	Systemic lupus erythematosus ( 26502338)
Interacting Genes		4 interacting genes: ALOX5 EIF4A3 GSK3A NAA10	59 interacting genes: ACOT12 BAALC BCOR CALCOCO2 CASP8AP2 CCDC106 CCDC174 CDC25A CEBPA CEP44 CFTR CREB3 CREBRF CTNNB1 DDIT4L DHX57 EHMT2 FIP1L1 GPATCH2L H4C1 HIF1A HIF1AN HSPA4 HYPK KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 MCRS1 MDM4 MEOX2 MKRN1 MRPS11 NAA15 NAA16 NAA50 NAT1 NAT2 NOXA1 PDE4DIP PGK1 PLSCR3 PPP2R3B PSME2 RAB3IP RBCK1 RCN3 RIMBP2 RPL26 SEMA3B SNX33 SSX2IP TAF7L TSEN54 UBC ZBTB14 ZNF202 ZNF655
Entrez ID		51244	8260
HPRD ID		12820	02056
Ensembl ID		ENSG00000154781	ENSG00000102030
Uniprot IDs		A0A0B4J1R8 Q6PII3	B7Z9N2 P41227
PDB IDs			6C95 6C9M 6PPL 6PW9 9F1B 9F1C 9F1D 9FPZ 9FQ0
Enriched GO Terms of Interacting Partners?		Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein-N-terminal-glutamate Acetyltransferase Activity Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Protein N-terminal-serine Acetyltransferase Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Arachidonate Metabolite Production Involved In Inflammatory Response Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Postsynapse Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Glycogen (starch) Synthase Activity Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion NatA Complex Selenocysteine Insertion Sequence Binding Negative Regulation Of Translational Elongation Regulation Of Translation At Postsynapse Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity Negative Regulation Of Vascular Wound Healing Cellular Response To Interleukin-3 Leukocyte Chemotaxis Involved In Inflammatory Response Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Brain-derived Neurotrophic Factor Stimulus Lipoxygenase Pathway Nuclear Envelope Lumen Cardiac Left Ventricle Morphogenesis Neuronal Cell Body Internal Protein Amino Acid Acetylation Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential	Acetyltransferase Activity NatA Complex Cytosol N-terminal Protein Amino Acid Acetylation Protein Binding Arylamine N-acetyltransferase Activity Nucleus Protein Acetylation
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